evpla envoplakin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: evplaprovided by ZNC
Official Full Name: envoplakin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030829-19
See related: Ensembl:ENSDARG00000019808 AllianceGenome:ZFIN:ZDB-GENE-030829-19
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: evpl; sb:cb742; si:ch211-157f15.1
Summary: Predicted to enable structural molecule activity. Predicted to be involved in intermediate filament cytoskeleton organization and wound healing. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and membrane. Predicted to colocalize with intermediate filament. Is expressed in several structures, including EVL; epidermis; pectoral fin musculature; periderm; and peripheral olfactory organ. Orthologous to human EVPL (envoplakin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (23057198..23081376)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (17959279..17983457)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
colocalizes_with intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: envoplakin a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001118897.1 → NP_001112369.1 envoplakin a

Status: PROVISIONAL

Source sequence(s)

CR450715

UniProtKB/TrEMBL

A0A8M1NG87, F1Q4X8

Related

ENSDARP00000021688.7, ENSDART00000026448.9

Conserved Domains (4) summary

smart00250
Location:1851 → 1886

PLEC; Plectin repeat

COG1196
Location:893 → 1656

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00681
Location:1814 → 1855

Plectin; Plectin repeat

cl02488
Location:215 → 361

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...