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    srsf6b serine and arginine rich splicing factor 6b [ Danio rerio (zebrafish) ]

    Gene ID: 494133, updated on 14-Nov-2024

    Summary

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    Official Symbol
    srsf6bprovided by ZNC
    Official Full Name
    serine and arginine rich splicing factor 6bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041219-1
    See related
    Ensembl:ENSDARG00000016783 AllianceGenome:ZFIN:ZDB-GENE-041219-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sfrs6; sfrs6b; wu:fc17h09; zgc:103497; wu:faa54g02
    Summary
    Predicted to enable mRNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to human SRSF6 (serine and arginine rich splicing factor 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See srsf6b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (1522135..1530865)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (1495610..1504277)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene phosphatase and actin regulator 3b Neighboring gene acyl-CoA thioesterase 8 Neighboring gene si:ch73-303b9.1 Neighboring gene intraflagellar transport 52 homolog (Chlamydomonas)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental features of DNA methylation during activation of the embryonic zebrafish genome. Andersen IS, et al. Genome Biol, 2012 Jul 25. PMID 22830626, Free PMC Article
    2. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
    3. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine and arginine rich splicing factor 6b
    Names
    serine/arginine-rich splicing factor 6b
    splicing factor, arginine/serine-rich 6
    splicing factor, arginine/serine-rich 6b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008732.1 → NP_001008732.1  serine and arginine rich splicing factor 6b

      See identical proteins and their annotated locations for NP_001008732.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086820
      UniProtKB/TrEMBL
      Q5M9N3
      Related
      ENSDARP00000022089.6, ENSDART00000002318.8
      Conserved Domains (3) summary
      COG0724
      Location:3 → 71
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12596
      Location:3 → 72
      RRM1_SRSF6; RNA recognition motif 1 in vertebrate serine/arginine-rich splicing factor 6 (SRSF6)
      cd12600
      Location:114 → 185
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      1522135..1530865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479605.2 → XP_021335280.1  serine and arginine rich splicing factor 6b isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLL5
      Conserved Domains (1) summary
      cd12600
      Location:48 → 119
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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