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    en2b engrailed homeobox 2b [ Danio rerio (zebrafish) ]

    Gene ID: 30238, updated on 9-Dec-2024

    Summary

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    Official Symbol
    en2bprovided by ZNC
    Official Full Name
    engrailed homeobox 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-40
    See related
    Ensembl:ENSDARG00000038868 AllianceGenome:ZFIN:ZDB-GENE-980526-40
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    en3; eng3; ENG-3; eng2b; ZF-EN-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate specification; midbrain development; and midbrain-hindbrain boundary development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mandibular muscle; midbrain hindbrain boundary neural plate; midbrain hindbrain boundary neural rod; and neural keel. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See en2b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (29976435..29979956)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (29992902..29996423)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene PAX interacting (with transcription-activation domain) protein 1 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a Neighboring gene canopy FGF signaling regulator 1 Neighboring gene RNA binding motif protein 33b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. H(2)O(2) and Engrailed 2 paracrine activity synergize to shape the zebrafish optic tectum. Amblard I, et al. Commun Biol, 2020 Sep 29. PMID 32994473, Free PMC Article
    2. The ELF-97 alkaline phosphatase substrate provides a bright, photostable, fluorescent signal amplification method for FISH. Paragas VB, et al. J Histochem Cytochem, 1997 Mar. PMID 9071316
    3. Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Pfeffer PL, et al. Development, 1998 Aug. PMID 9671580
    4. Formation of the zebrafish midbrain-hindbrain boundary constriction requires laminin-dependent basal constriction. Gutzman JH, et al. Mech Dev, 2008 Nov-Dec. PMID 18682291, Free PMC Article
    5. Diversity of expression of engrailed-like antigens in zebrafish. Hatta K, et al. Development, 1991 Jul. PMID 1682127

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within midbrain development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within midbrain-hindbrain boundary development IGI
    Inferred from Genetic Interaction
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein engrailed-2b
    Names
    engrailed 2b
    engrailed 3
    homeobox protein en-2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131040.1 → NP_571115.1  homeobox protein engrailed-2b

      See identical proteins and their annotated locations for NP_571115.1

      Status: PROVISIONAL

      Source sequence(s)
      X68447
      UniProtKB/Swiss-Prot
      P31533
      Related
      ENSDARP00000056747.3, ENSDART00000056748.4
      Conserved Domains (2) summary
      pfam00046
      Location:175 → 228
      Homeobox; Homeobox domain
      pfam10525
      Location:230 → 259
      Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      29976435..29979956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31533.2 GenPept UniProtKB/Swiss-Prot:P31533

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