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    snx17 sorting nexin 17 [ Danio rerio (zebrafish) ]

    Gene ID: 568263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snx17provided by ZNC
    Official Full Name
    sorting nexin 17provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9475
    See related
    Ensembl:ENSDARG00000091418 AllianceGenome:ZFIN:ZDB-GENE-030131-9475
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb67g03; wu:fb67g09; wu:fc27g08; wu:fj81d04; si:ch211-101l18.2
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to act upstream of or within protein transport and signal transduction. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be active in early endosome. Is expressed in brain; eye; liver; and pancreas. Orthologous to human SNX17 (sorting nexin 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See snx17 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (19436189..19511631, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (19536604..19612057, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-278j3.3 Neighboring gene zinc finger protein 513a Neighboring gene all-trans retinoic acid-induced differentiation factor Neighboring gene eukaryotic translation initiation factor 2B, subunit 4 delta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. SNX27-FERM-SNX1 complex structure rationalizes divergent trafficking pathways by SNX17 and SNX27. Yong X, et al. Proc Natl Acad Sci U S A, 2021 Sep 7. PMID 34462354, Free PMC Article
    2. SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1. Yin W, et al. Cell Regen, 2012. PMID 25408867, Free PMC Article
    3. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
    4. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
    5. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045157.3 → NP_001038622.2  sorting nexin-17

      See identical proteins and their annotated locations for NP_001038622.2

      Status: PROVISIONAL

      Source sequence(s)
      BC162993
      UniProtKB/TrEMBL
      A0A0R4ITX6
      Related
      ENSDARP00000137695.1, ENSDART00000168521.2
      Conserved Domains (3) summary
      cd06885
      Location:2 → 105
      PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
      cd13337
      Location:268 → 388
      FERM-like_C_SNX17; Atypical FERM-like domain C-lobe of Sorting nexin 17
      cl00155
      Location:115 → 185
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      19436189..19511631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294624.3 → XP_009292899.1  sorting nexin-17 isoform X1

      See identical proteins and their annotated locations for XP_009292899.1

      UniProtKB/Swiss-Prot
      B3DI45, Q5RID7
      Related
      ENSDARP00000040190.4, ENSDART00000040191.6
      Conserved Domains (3) summary
      cd06885
      Location:2 → 105
      PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
      cd13337
      Location:268 → 388
      FERM-like_C_SNX17; Atypical FERM-like domain C-lobe of Sorting nexin 17
      cl00155
      Location:115 → 185
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RID7.1 GenPept UniProtKB/Swiss-Prot:Q5RID7

    Gene LinkOut

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