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    hoxa10b homeobox A10b [ Danio rerio (zebrafish) ]

    Gene ID: 30391, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hoxa10bprovided by ZNC
    Official Full Name
    homeobox A10bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-97
    See related
    Ensembl:ENSDARG00000031337 AllianceGenome:ZFIN:ZDB-GENE-990415-97
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    z-140; hoxa10; Hoxa-10
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including CNS interneuron; chondroblast; mesenchyme; myoblast; and pectoral fin bud. Orthologous to human HOXA10 (homeobox A10). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hoxa10b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (20910075..20913003)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (21103735..21107184)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene homeobox A13b Neighboring gene homeobox A11b Neighboring gene microRNA 196d Neighboring gene homeobox A9b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A compact, in vivo screen of all 6-mers reveals drivers of tissue-specific expression and guides synthetic regulatory element design. Smith RP, et al. Genome Biol, 2013 Jul 18. PMID 23867016, Free PMC Article
    2. Bichir HoxA cluster sequence reveals surprising trends in ray-finned fish genomic evolution. Chiu CH, et al. Genome Res, 2004 Jan. PMID 14707166, Free PMC Article
    3. Genomic organization of the Hoxa4-Hoxa10 region from Morone saxatilis: implications for Hox gene evolution among vertebrates. Snell EA, et al. J Exp Zool, 1999 Apr 15. PMID 10327649
    4. Studying the effects of genistein on gene expression of fish embryos as an alternative testing approach for endocrine disruption. Schiller V, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2013 Jan. PMID 23017276
    5. Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism. Messina A, et al. Am J Hum Genet, 2020 Jan 2. PMID 31883645, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Hox-A10b
    Names
    homeo box A10b
    homeobox gene A-10
    hox-A10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131155.2 → NP_571230.2  homeobox protein Hox-A10b

      Status: VALIDATED

      Source sequence(s)
      CR392024
      UniProtKB/Swiss-Prot
      O57357, Q4PRA5, Q8AWY2
      UniProtKB/TrEMBL
      B3DGC1
      Related
      ENSDARP00000046765.4, ENSDART00000046766.5
      Conserved Domains (1) summary
      pfam00046
      Location:276 → 329
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      20910075..20913003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157954.5 → XP_005158011.1  homeobox protein Hox-A10b isoform X1

      UniProtKB/Swiss-Prot
      O57357, Q4PRA5, Q8AWY2
      UniProtKB/TrEMBL
      A0A8M2B4B4, B3DGC1
      Conserved Domains (1) summary
      pfam00046
      Location:275 → 328
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8AWY2.1 GenPept UniProtKB/Swiss-Prot:Q8AWY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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