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    ajuba ajuba LIM protein [ Danio rerio (zebrafish) ]

    Gene ID: 572549, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ajubaprovided by ZNC
    Official Full Name
    ajuba LIM proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9341
    See related
    Ensembl:ENSDARG00000077842 AllianceGenome:ZFIN:ZDB-GENE-030131-9341
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    jub; fj66b05; wu:fj66b05
    Summary
    Predicted to enable transcription corepressor activity. Acts upstream of or within heart development. Predicted to be part of transcription regulator complex. Predicted to be active in P-body; adherens junction; and nucleus. Is expressed in head. Orthologous to human AJUBA (ajuba LIM protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ajuba in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (24100200..24112451, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (23829001..23841426, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U6-53/MBII-28 Neighboring gene apoptotic chromatin condensation inducer 1b Neighboring gene small nucleolar RNA U6-53/MBII-28 Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene matrix metallopeptidase 14a (membrane-inserted)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Witzel HR, et al. Dev Cell, 2012 Jul 17. PMID 22771034, Free PMC Article
    2. Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Szenker-Ravi E, et al. Nat Genet, 2022 Jan. PMID 34903892
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein ajuba; LIM domain-containing protein ajuba
    Names
    jub, ajuba homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      24100200..24112451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_696274.10 → XP_701366.4  LIM domain-containing protein ajuba

      UniProtKB/TrEMBL
      A0A8N7TEU1, E7FFI0
      Related
      ENSDARP00000100146.2, ENSDART00000111923.5
      Conserved Domains (3) summary
      cd09352
      Location:486 → 539
      LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins
      cd09355
      Location:551 → 603
      LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins
      cd09438
      Location:611 → 672
      LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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