socs3a suppressor of cytokine signaling 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: socs3aprovided by ZNC
Official Full Name: suppressor of cytokine signaling 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7349
See related: Ensembl:ENSDARG00000025428 AllianceGenome:ZFIN:ZDB-GENE-030131-7349
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: socs3; fj09e12; zgc:56537; wu:fj09e12
Summary: Predicted to enable cytokine receptor binding activity. Acts upstream of or within several processes, including hepatocyte differentiation; negative regulation of axon regeneration; and sensory system development. Is expressed in eye; female organism; lateral line; liver; and male organism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (57423137..57425959, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (57352613..57355435, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq and Socs3a
Title: Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq.
stat3/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Title: The stat3/socs3a pathway is a key regulator of hair cell regeneration in zebrafish. [corrected].
Trpm7 regulates exocrine pancreatic development via the Mg(2+)-sensitive Socs3a pathway.
Title: Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer.
in homozygotes, GH signaling is reduced by the action of the SOCS1 and SOCS3 proteins.
Title: SOCS1 and SOCS3 are the main negative modulators of the somatotrophic axis in liver of homozygous GH-transgenic zebrafish (Danio rerio).
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
Title: Identification and characterization of suppressor of cytokine signaling 3 (SOCS-3) homologues in teleost fish.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase pathway by chemical inhibitors
Title: Expression of Xenopus suppressor of cytokine signaling 3 (xSOCS3) is induced by epithelial wounding.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hepatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within posterior lateral line neuromast hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regeneration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: suppressor of cytokine signaling 3a

Names: suppressor of cytokine signaling 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199950.1 → NP_956244.1 suppressor of cytokine signaling 3a

See identical proteins and their annotated locations for NP_956244.1

Status: PROVISIONAL

Source sequence(s)

BC049326

UniProtKB/TrEMBL

A0A8M1PG52, Q7ZUC6

Related

ENSDARP00000038723.4, ENSDART00000033716.5

Conserved Domains (2) summary

cd10384
Location:40 → 139

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:167 → 207

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...