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    c4 complement component 4 [ Danio rerio (zebrafish) ]

    Gene ID: 566261, updated on 2-Nov-2024

    Summary

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    Official Symbol
    c4provided by ZNC
    Official Full Name
    complement component 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5697
    See related
    Ensembl:ENSDARG00000015065 AllianceGenome:ZFIN:ZDB-GENE-030131-5697
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fi14a03
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in several cellular components, including axon; dendrite; and synapse. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficiency (multiple); and renal cell carcinoma. Orthologous to human C4A (complement C4A (Chido/Rodgers blood group)); C4B (complement C4B (Chido/Rodgers blood group)); and C4B_2 (complement component 4B (Chido/Rodgers blood group), copy 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (32353475..32383452, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (32494101..32525477, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor interacting protein 2a Neighboring gene FH2 domain containing 4 Neighboring gene tripartite motif containing 3a Neighboring gene si:ch211-162k9.5 Neighboring gene si:dkey-285b23.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fish complement C4 gene evolution and gene/protein regulatory network analyses and simulated stereo conformation of C4-MASP-2 protein complex. Li L, et al. Fish Shellfish Immunol, 2020 Dec. PMID 32980531
    2. Linkage relationships of genes coding for alpha2-macroglobulin, C3 and C4 in the zebrafish: implications for the evolution of the complement and Mhc systems. Samonte IE, et al. Scand J Immunol, 2002 Oct. PMID 12234255
    3. Response of complement expression to challenge with lipopolysaccharide in embryos/larvae of zebrafish Danio rerio: acquisition of immunocompetent complement. Wang Z, et al. Fish Shellfish Immunol, 2008 Sep. PMID 18657447
    4. An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection. Pereiro P, et al. Front Immunol, 2022. PMID 36713462, Free PMC Article
    5. A Temporal Map of Gene Expression Pattern During Zebrafish Liver Regeneration. Jagtap U, et al. Zebrafish, 2020 Feb. PMID 31770088

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    complement C4-B
    Names
    complement component 4A
    complement component 4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      32353475..32383452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466464.2 → XP_021322139.1  complement C4-B isoform X2

      UniProtKB/TrEMBL
      A0A8M9PCH5
      Conserved Domains (7) summary
      cd00017
      Location:675 → 731
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:977 → 1276
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      pfam00207
      Location:766 → 856
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1414 → 1502
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:457 → 597
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      cl02512
      Location:1520 → 1678
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

    2. XM_005157372.5 → XP_005157429.1  complement C4-B isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3G6, F1Q4X5
      Related
      ENSDARP00000031658.5, ENSDART00000028349.8
      Conserved Domains (8) summary
      cd00017
      Location:675 → 731
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:977 → 1276
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      cd03584
      Location:1540 → 1698
      NTR_complement_C4; NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical ...
      pfam00207
      Location:766 → 856
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:128 → 220
      A2M_N; MG2 domain
      pfam07677
      Location:1434 → 1522
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1032 → 1278
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:459 → 595
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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