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    got2b glutamic-oxaloacetic transaminase 2b, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 335974, updated on 2-Nov-2024

    Summary

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    Official Symbol
    got2bprovided by ZNC
    Official Full Name
    glutamic-oxaloacetic transaminase 2b, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7917
    See related
    Ensembl:ENSDARG00000005840 AllianceGenome:ZFIN:ZDB-GENE-030131-7917
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj40h07; zgc:56425; wu:fj40h07
    Summary
    Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate catabolic process. Predicted to act upstream of or within amino acid metabolic process and biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See got2b in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (51774564..51793881)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (51499494..51518811)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene liver-expressed antimicrobial peptide 2 Neighboring gene bone morphogenetic protein 15 Neighboring gene uncharacterized LOC137496218 Neighboring gene solute carrier family 38 member 7 Neighboring gene si:ch211-122f10.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish. Wu X, et al. Int J Mol Sci, 2022 Apr 11. PMID 35457018, Free PMC Article
    2. Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2019 Nov 11. PMID 31712630, Free PMC Article
    3. UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Zhang J, et al. Environ Pollut, 2020 Nov. PMID 32798906
    4. Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. Gebriel M, et al. J Neurosci Res, 2014 Jan. PMID 24123299
    5. Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish. Lam SH, et al. PLoS One, 2011. PMID 22194820, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-aspartate:2-oxoglutarate aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aspartate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamic-oxaloacetic transaminase 2b, mitochondrial
    Names
    glutamate oxaloacetate transaminase 2
    glutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)
    NP_956283.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199989.1 → NP_956283.1  glutamic-oxaloacetic transaminase 2b, mitochondrial

      See identical proteins and their annotated locations for NP_956283.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049435
      UniProtKB/TrEMBL
      Q7ZWF5
      Related
      ENSDARP00000024560.5, ENSDART00000007767.6
      Conserved Domains (2) summary
      PLN02397
      Location:26 → 428
      PLN02397; aspartate transaminase
      pfam00155
      Location:55 → 423
      Aminotran_1_2; Aminotransferase class I and II

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      51774564..51793881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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