thumpd3 THUMP domain containing 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: thumpd3provided by ZNC
Official Full Name: THUMP domain containing 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9745
See related: Ensembl:ENSDARG00000059634 AllianceGenome:ZFIN:ZDB-GENE-030131-9745
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb255; sb:cb255; zgc:163086
Summary: Predicted to enable tRNA (guanine) methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation. Predicted to be located in cytoplasm. Is expressed in several structures, including alar plate midbrain region; immature eye; mesoderm; musculature system; and nervous system. Orthologous to human THUMPD3 (THUMP domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (21993586..22022637)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (19933331..19962420)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi03g09.x1 (e-PCR)
- UniSTS:196624

fc87f11.y1 (e-PCR)
- UniSTS:194713

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine) methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA (guanine(6)-N2)-methyltransferase THUMP3

NP_001082863.1

EC 2.1.1.256

XP_068077854.1

EC 2.1.1.256

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089394.2 → NP_001082863.1 tRNA (guanine(6)-N2)-methyltransferase THUMP3

See identical proteins and their annotated locations for NP_001082863.1

Status: PROVISIONAL

Source sequence(s)

BC134225

UniProtKB/TrEMBL

A3KP95

Related

ENSDARP00000077505.2, ENSDART00000083070.4

Conserved Domains (2) summary

cd11715
Location:10 → 248

THUMP_AdoMetMT; THUMP domain associated with S-adenosylmethionine-dependent methyltransferases

cl17173
Location:255 → 437

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...