desi2 desumoylating isopeptidase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: desi2provided by ZNC
Official Full Name: desumoylating isopeptidase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-39
See related: Ensembl:ENSDARG00000004460 AllianceGenome:ZFIN:ZDB-GENE-040801-39
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb238; desi1; DeSI-2; pppde1; fi12d12; sb:cb238; wu:fi12d12; zgc:100860
Summary: Predicted to enable deubiquitinase activity and long-chain fatty acyl-CoA hydrolase activity. Acts upstream of or within convergent extension involved in gastrulation. Predicted to be located in cytoplasm. Is expressed in several structures, including margin; nervous system; neural plate; neural tube; and trunk. Orthologous to human DESI2 (desumoylating isopeptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (11550454..11570568)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (11417979..11438093)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that Pnas4 is a key regulator of cell movement during gastrulation.
Title: Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables palmitoyl-(protein) hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: deubiquitinase DESI2

Names: PPPDE peptidase domain containing 1; PPPDE peptidase domain-containing protein 1; S-depalmitoylase DESI2; desumoylating isopeptidase 1; fam152a; palmitoyl protein thioesterase DESI2; pnas4

NP_001003532.1

EC 3.1.2.22

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.