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    dennd6b DENN/MADD domain containing 6B [ Danio rerio (zebrafish) ]

    Gene ID: 337436, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dennd6bprovided by ZNC
    Official Full Name
    DENN/MADD domain containing 6Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9382
    See related
    Ensembl:ENSDARG00000011605 AllianceGenome:ZFIN:ZDB-GENE-030131-9382
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fam116b; fj67e07; zgc:55619; wu:fj67e07
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in recycling endosome. Is expressed in central nervous system; cranial ganglion; retina; telencephalon; and yolk syncytial layer. Orthologous to human DENND6B (DENN domain containing 6B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See dennd6b in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20071128..20081659, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (20082149..20092720, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene zmp:0000000938 Neighboring gene GRIP and coiled-coil domain containing 1 Neighboring gene protein phosphatase 6, regulatory subunit 2a Neighboring gene coiled-coil domain containing 146 Neighboring gene FAM3 metabolism regulating signaling molecule C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Vejnar CE, et al. Genome Res, 2019 Jul. PMID 31227602, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein DENND6B
    Names
    family with sequence similarity 116, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200065.1 → NP_956359.1  protein DENND6B

      See identical proteins and their annotated locations for NP_956359.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044201
      UniProtKB/TrEMBL
      Q803T4
      Related
      ENSDARP00000008404.7, ENSDART00000024647.8
      Conserved Domains (2) summary
      pfam08616
      Location:242 → 348
      SPA; Stabilization of polarity axis
      cl11519
      Location:143 → 293
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      20071128..20081659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164716.5 → XP_005164773.1  protein DENND6B isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBU9
      Conserved Domains (2) summary
      pfam08616
      Location:242 → 348
      SPA; Stabilization of polarity axis
      cl11519
      Location:143 → 293
      DENN; DENN (AEX-3) domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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