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    snap25a synaptosome associated protein 25a [ Danio rerio (zebrafish) ]

    Gene ID: 30712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snap25aprovided by ZNC
    Official Full Name
    synaptosome associated protein 25aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-468
    See related
    Ensembl:ENSDARG00000020609 AllianceGenome:ZFIN:ZDB-GENE-980526-468
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Snap; snap25; fj42b02; fj45g04; fj48c02; snap25.1; wu:fj42b02; wu:fj45g04; wu:fj48c02
    Summary
    Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Acts upstream of or within locomotory behavior and mitotic cytokinesis. Located in plasma membrane. Is expressed in head; nervous system; and optic vesicle. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See snap25a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (34913069..34956043)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (35010157..35056189)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene elastin microfibril interfacer 1a Neighboring gene ankyrin repeat and EF-hand domain containing 1a Neighboring gene saccharopine dehydrogenase b Neighboring gene uncharacterized LOC110438184 Neighboring gene consortin, connexin sorting protein b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Replacing SNAP-25b with SNAP-25a expression results in metabolic disease. Valladolid-Acebes I, et al. Proc Natl Acad Sci U S A, 2015 Aug 4. PMID 26195742, Free PMC Article
    2. Recruitment and SNARE-mediated fusion of vesicles in furrow membrane remodeling during cytokinesis in zebrafish embryos. Li WM, et al. Exp Cell Res, 2006 Oct 15. PMID 16876784
    3. RBFOX1 and Working Memory: From Genome to Transcriptome Revealed Posttranscriptional Mechanism Separate From Attention-Deficit/Hyperactivity Disorder. Zhong Y, et al. Biol Psychiatry Glob Open Sci, 2023 Oct. PMID 37881587, Free PMC Article
    4. miR-153 regulates SNAP-25, synaptic transmission, and neuronal development. Wei C, et al. PLoS One, 2013. PMID 23451149, Free PMC Article
    5. Spatiotemporal expression profile of embryonic and adult ankyrin repeat and EF-hand domain containing protein 1-encoding genes ankef1a and ankef1b in zebrafish. Daniel JG, et al. Gene Expr Patterns, 2019 Dec. PMID 31520739

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular analysis of ndrg4 mutants shows that expression of snap25 and nsf are sharply decreased, revealing a role of ndrg4 in controlling vesicle exocytosis. This uncovers a previously unknown function of ndrg4 in regulating vesicle docking and nodes of Ranvier organization, at least through its ability to finely tune the expression of the t-SNARE/NSF machinery.
      Title: Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish.
    2. a mouse mutant engineered to express normal levels of SNAP-25 but only SNAP-25a shows metabolic disease.
      Title: Replacing SNAP-25b with SNAP-25a expression results in metabolic disease.
    3. results indicate that precise control of SNAP-25 expression by miR-153 is critically important for proper neuronal patterning as well as neurotransmission
      Title: miR-153 regulates SNAP-25, synaptic transmission, and neuronal development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin-1 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of BLOC-1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptosomal-associated protein 25-A
    Names
    etID17571.20
    etID69167.20
    synaptosomal-associated protein, 25a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131435.1 → NP_571510.1  synaptosomal-associated protein 25-A

      See identical proteins and their annotated locations for NP_571510.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063942
      UniProtKB/Swiss-Prot
      Q5TZ66
      Related
      ENSDARP00000019054.5, ENSDART00000007584.8
      Conserved Domains (3) summary
      cd15885
      Location:141 → 199
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:10 → 82
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91 → 139
      SNAP-25; SNAP-25 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      34913069..34956043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160623.5 → XP_005160680.1  synaptosomal-associated protein 25-A isoform X1

      UniProtKB/Swiss-Prot
      Q5TZ66
      Related
      ENSDARP00000062737.6, ENSDART00000062738.7
      Conserved Domains (3) summary
      cd15885
      Location:141 → 199
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:10 → 82
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91 → 139
      SNAP-25; SNAP-25 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TZ66.1 GenPept UniProtKB/Swiss-Prot:Q5TZ66

    Gene LinkOut

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