U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    igfbp2a insulin-like growth factor binding protein 2a [ Danio rerio (zebrafish) ]

    Gene ID: 794176, updated on 2-Nov-2024

    Summary

    Official Symbol
    igfbp2aprovided by ZNC
    Official Full Name
    insulin-like growth factor binding protein 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000125-12
    See related
    Ensembl:ENSDARG00000052470 AllianceGenome:ZFIN:ZDB-GENE-000125-12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    igfbp2; igfbp2b
    Summary
    Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in negative regulation of DNA replication; negative regulation of developmental growth; and regulation of insulin-like growth factor receptor signaling pathway. Acts upstream of or within circulatory system development; negative regulation of cell population proliferation; and regulation of growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including gonad; head; immature eye; nervous system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See igfbp2a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (20921546..20952178, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (18861324..18891956, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene tensin 1a Neighboring gene insulin-like growth factor binding protein 5a Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene gap junction protein gamma 4a.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC65741, MGC76823, MGC174445

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables insulin-like growth factor I binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables insulin-like growth factor II binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin-like growth factor binding IDA
    Inferred from Direct Assay
    more info
     
    enables insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    insulin-like growth factor-binding protein 2-A
    Names
    IGF-binding protein 2-A
    IGFBP-2-A
    IGFBP-2a
    insulin-like growth factor binding protein 2
    insulin-like growth factor binding protein 2b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131458.2NP_571533.1  insulin-like growth factor-binding protein 2-A precursor

      See identical proteins and their annotated locations for NP_571533.1

      Status: PROVISIONAL

      Source sequence(s)
      AF198033
      UniProtKB/Swiss-Prot
      A8E5I5, Q9PTH3
      Related
      ENSDARP00000068816.4, ENSDART00000074327.5
      Conserved Domains (2) summary
      smart00121
      Location:26102
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:180259
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      20921546..20952178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394633.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      120640..173015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)