cdc42se1 CDC42 small effector 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdc42se1provided by ZNC
Official Full Name: CDC42 small effector 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9260
See related: Ensembl:ENSDARG00000023724 AllianceGenome:ZFIN:ZDB-GENE-030131-9260
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: spec1; zgc:55642; wu:fa55c04; wu:fc05d06
Summary: Predicted to enable small GTPase binding activity. Acts upstream of or within midbrain-hindbrain boundary morphogenesis. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be active in plasma membrane. Is expressed in primordial germ cell. Orthologous to human CDC42SE1 (CDC42 small effector 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (38311887..38333991, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (38361855..38383959, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc05d06.x1 (e-PCR)
- UniSTS:187702

fa55c04.s1 (e-PCR)
- UniSTS:197786

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell shape	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: CDC42 small effector protein 1

Names: small protein effector 1 of Cdc42

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200060.3 → NP_956354.1 CDC42 small effector protein 1

See identical proteins and their annotated locations for NP_956354.1

Status: VALIDATED

Source sequence(s)

AL929190, EB890912, EB933762, EB978640, EB983056, EH582597, EH593343

UniProtKB/Swiss-Prot

Q6TEL3

Related

ENSDARP00000034273.4, ENSDART00000031895.5

Conserved Domains (1) summary

cl00113
Location:29 → 43

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...