ddx27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ddx27provided by ZNC
Official Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 27provided by ZNC
Primary source: ZFIN:ZDB-GENE-031001-8
See related: Ensembl:ENSDARG00000091831 AllianceGenome:ZFIN:ZDB-GENE-031001-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb843
Summary: Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Acts upstream of or within rRNA processing. Predicted to be active in nucleolus. Is expressed in several structures, including alar plate midbrain region; brain; digestive system; musculature system; and retina. Orthologous to human DDX27 (DEAD-box helicase 27). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (57436314..57476465, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (57439450..57479601, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDX27 regulates ribosomal RNA maturation, and thereby the ribosome biogenesis and the translation of specific transcripts during myogenesis.
Title: RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX27

NP_001002869.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002869.1 → NP_001002869.1 probable ATP-dependent RNA helicase DDX27

See identical proteins and their annotated locations for NP_001002869.1

Status: PROVISIONAL

Source sequence(s)

AY648729

UniProtKB/TrEMBL

Q6DRN0

Related

ENSDARP00000105288.1, ENSDART00000128065.3

Conserved Domains (3) summary

COG0513
Location:202 → 673

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd00268
Location:203 → 407

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:432 → 541

Helicase_C; Helicase conserved C-terminal domain