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    acy1 aminoacylase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393970, updated on 14-Nov-2024

    Summary

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    Official Symbol
    acy1provided by ZNC
    Official Full Name
    aminoacylase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-755
    See related
    Ensembl:ENSDARG00000038475 AllianceGenome:ZFIN:ZDB-GENE-040426-755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55605; zgc:76955; si:zfos-226g1.1
    Summary
    Predicted to enable aminoacylase activity. Predicted to act upstream of or within amino acid metabolic process. Predicted to be located in cytoplasm. Is expressed in lens; liver; peripheral olfactory organ; pronephric duct; and pronephros. Orthologous to human ACY1 (aminoacylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See acy1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (36755280..36774249, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (36786269..36816206, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase TRIM35-like Neighboring gene tripartite motif containing 35-44 Neighboring gene aminoacylase-1A-like Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene interferon induced protein 44g

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Peng X, et al. Leukemia, 2015 Dec. PMID 26104663, Free PMC Article
    2. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. Liu Z, et al. J Biol Chem, 2011 Aug 12. PMID 21669877, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55605

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminoacylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aminoacylase-1
    NP_001259009.1
    NP_957289.2
    XP_068072366.1
    XP_068072367.1
    XP_068072368.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272080.1 → NP_001259009.1  aminoacylase-1

      See identical proteins and their annotated locations for NP_001259009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CU896698
      UniProtKB/TrEMBL
      A0A0R4IW78, A0A8M1PFF1, F1QZ04
      Related
      ENSDARP00000141987.1, ENSDART00000168711.2
      Conserved Domains (2) summary
      cd05646
      Location:21 → 411
      M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
      TIGR01880
      Location:21 → 413
      Ac-peptdase-euk; N-acyl-L-amino-acid amidohydrolase

    2. NM_200995.2 → NP_957289.2  aminoacylase-1

      See identical proteins and their annotated locations for NP_957289.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CU896698
      UniProtKB/TrEMBL
      A0A0R4IW78, A0A8M1PFF1, F1QZ04
      Related
      ENSDARP00000056150.5, ENSDART00000056151.7
      Conserved Domains (2) summary
      cd05646
      Location:21 → 411
      M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
      TIGR01880
      Location:21 → 413
      Ac-peptdase-euk; N-acyl-L-amino-acid amidohydrolase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      36755280..36774249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216265.1 → XP_068072366.1  aminoacylase-1 isoform X1

    2. XM_068216266.1 → XP_068072367.1  aminoacylase-1 isoform X1

    3. XM_068216267.1 → XP_068072368.1  aminoacylase-1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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