cox5ab cytochrome c oxidase subunit 5Ab [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cox5abprovided by ZNC
Official Full Name: cytochrome c oxidase subunit 5Abprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5162
See related: Ensembl:ENSDARG00000099663 AllianceGenome:ZFIN:ZDB-GENE-030131-5162
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cox5a; Cox5a2; cb01f09; mg:cb01f09
Summary: Enables cytochrome-c oxidase activity. Acts upstream of or within embryonic organ development; proton transmembrane transport; and spinal cord motor neuron differentiation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in brain; gill; heart; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 20. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (808911..812753)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (892080..895922, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of developmental pathology due to cytochrome c oxidase deficiency
Title: Early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model.

Submit: New GeneRIF Correction

General gene information

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Markers

fk49a06.x1 (e-PCR)
- UniSTS:201071

AI106288 (e-PCR)
- UniSTS:206839

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytochrome-c oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 5Ab

Names: cytochrome c oxidase subunit Va; cytochrome c oxidase subunit Vab

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305577.1 → NP_001292506.1 cytochrome c oxidase subunit 5Ab

Status: VALIDATED

Source sequence(s)

CABZ01078337, EH437300, EH483108, EH546885

UniProtKB/TrEMBL

A0A0R4IVC8, A0A8M1P7E4

Related

ENSDARP00000138508.1, ENSDART00000172518.2

Conserved Domains (1) summary

cd00923
Location:33 → 134

Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...