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    mpl MPL proto-oncogene, thrombopoietin receptor [ Danio rerio (zebrafish) ]

    Gene ID: 445381, updated on 14-Nov-2024

    Summary

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    Official Symbol
    mplprovided by ZNC
    Official Full Name
    MPL proto-oncogene, thrombopoietin receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060421-1
    See related
    Ensembl:ENSDARG00000039222 AllianceGenome:ZFIN:ZDB-GENE-060421-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mpll; tpor; c-mpl; tpor.b
    Summary
    Predicted to enable cytokine receptor activity. Acts upstream of or within thrombocyte differentiation. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in blood; nucleate erythrocyte; thrombocyte; and ventral wall of dorsal aorta. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mpl in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (33949107..33980908, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (33964265..33996191, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 38A Neighboring gene origin recognition complex, subunit 1 Neighboring gene lnc RNA tyrosine kinase with immunoglobulin-like and EGF-like domains 1, antisense Neighboring gene tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Neighboring gene si:ch73-185c24.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Detection of nucleotide-specific CRISPR/Cas9 modified alleles using multiplex ligation detection. Kc R, et al. Sci Rep, 2016 Aug 25. PMID 27557703, Free PMC Article
    2. Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Lin HF, et al. Blood, 2005 Dec 1. PMID 16099879, Free PMC Article
    3. Thrombocyte Inhibition Restores Protective Immunity to Mycobacterial Infection in Zebrafish. Hortle E, et al. J Infect Dis, 2019 Jul 2. PMID 30877311, Free PMC Article
    4. In vivo inactivation of MASTL kinase results in thrombocytopenia. Johnson HJ, et al. Exp Hematol, 2009 Aug. PMID 19460416, Free PMC Article
    5. Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb. Grabher C, et al. Leukemia, 2011 Mar. PMID 21079614, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within thrombocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thrombopoietin receptor
    Names
    cytokine receptor
    myeloproliferative leukemia virus oncogene, like
    thrombopoietin receptor c-mpl

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003858.1 → NP_001003858.1  thrombopoietin receptor precursor

      See identical proteins and their annotated locations for NP_001003858.1

      Status: PROVISIONAL

      Source sequence(s)
      AY319287
      UniProtKB/TrEMBL
      Q6EIY6
      Related
      ENSDARP00000109739.2, ENSDART00000124917.4
      Conserved Domains (2) summary
      cd00063
      Location:314 → 403
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09067
      Location:23 → 122
      EpoR_lig-bind; Erythropoietin receptor, ligand binding

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      33949107..33980908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166280.5 → XP_005166337.1  thrombopoietin receptor isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDQ1
      Related
      ENSDARP00000057296.6, ENSDART00000057297.6
      Conserved Domains (2) summary
      cd00063
      Location:341 → 430
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09067
      Location:50 → 149
      EpoR_lig-bind; Erythropoietin receptor, ligand binding

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395259.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      258284..294397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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