ar androgen receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arprovided by ZNC
Official Full Name: androgen receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060131-1
See related: Ensembl:ENSDARG00000067976 AllianceGenome:ZFIN:ZDB-GENE-060131-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NR3C4
Summary: Enables androgen binding activity and nuclear steroid receptor activity. Acts upstream of or within several processes, including male courtship behavior; male gonad development; and oocyte maturation. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including Leydig cell; brain; digestive system; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; disorder of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Orthologous to human AR (androgen receptor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (35561341..35680989)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (34961188..35080836)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The miRNAs 203a/210-3p/5001-5p regulate the androgen/androgen receptor/YAP-induced migration in prostate cancer cells.
Title: The miRNAs 203a/210-3p/5001-5p regulate the androgen/androgen receptor/YAP-induced migration in prostate cancer cells.
In summary, our results provided unequivocal in vivo evidence for the requirement of functional ar in maintaining normal spermatogenesis and steroidogenesis, in ensuring normal fertility in male zebrafish.
Title: Fertility impairment with defective spermatogenesis and steroidogenesis in male zebrafish lacking androgen receptor.
Using glucose as a disease-relevant readout, we screened 2233 molecules and identified three that consistently reduced glucose levels in insulin mutants. Most significantly, we uncovered an insulin-independent beneficial role for androgen receptor antagonism in hyperglycemia, mostly by reducing fasting glucose levels.
Title: Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists.
Zebrafish males lacking the androgen receptor courted females significantly less, showing reduced levels of stereotypic behaviors. Consistent with previous studies, disrupting androgen mechanisms can lead to behavioral changes with potential fitness consequences.
Title: Genetic editing of the androgen receptor contributes to impaired male courtship behavior in zebrafish.
AR regulates sexual determination, testis development, and oocyte maturation and AR regulates sexually dimorphic gene expression. The ar mutant developed will be useful for modeling human endocrine function in zebrafish.
Title: Nuclear Androgen Receptor Regulates Testes Organization and Oocyte Maturation in Zebrafish.
Findings suggest that zebrafish embryos attempt to compensate for the presence of an anti-androgen by increasing the number of androgen receptors available.
Title: Zebrafish (Danio rerio) androgen receptor: sequence homology and up-regulation by the fungicide vinclozolin.
ar was expressed in discrete regions of the telencephalon, in the preoptic area, and throughout the periventricular hypothalamus, regions previously implicated in the regulation of sexually dimorphic behaviors in mammals
Title: Androgen receptor gene expression in the developing and adult zebrafish brain.
The isolation and characterization of zebrafish Ar were reported.
Title: Zebrafish androgen receptor: isolation, molecular, and biochemical characterization.

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General gene information

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Markers

z1390 (e-PCR), detects polymorphism
- UniSTS:205126

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables androgen binding	IDA Inferred from Direct Assay more info	PubMed
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear steroid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: androgen receptor

Names: AR-A; Ar beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083123.1 → NP_001076592.1 androgen receptor

See identical proteins and their annotated locations for NP_001076592.1

Status: PROVISIONAL

Source sequence(s)

EF427915

UniProtKB/TrEMBL

A0A8M1NDR7, A4GT83

Related

ENSDARP00000088795.3, ENSDART00000098022.4

Conserved Domains (2) summary

cd07173
Location:507 → 588

NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers

cl11397
Location:622 → 867

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

35561341..35680989

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171775.3 → XP_005171832.1 androgen receptor isoform X1

UniProtKB/TrEMBL

A0A8M2BJ05

Conserved Domains (2) summary

cd07173
Location:24 → 105

NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers

cl11397
Location:139 → 384

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators