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    Gskip GSK3B interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 66787, updated on 28-Oct-2024

    Summary

    Official Symbol
    Gskipprovided by MGI
    Official Full Name
    GSK3B interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1914037
    See related
    Ensembl:ENSMUSG00000044715 AllianceGenome:MGI:1914037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933433P14Rik
    Summary
    Predicted to enable protein kinase A regulatory subunit binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of protein kinase activity; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; liver; metanephros; spleen; and testis. Orthologous to human GSKIP (GSK3B interacting protein). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 14.1), large intestine adult (RPKM 7.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gskip in Genome Data Viewer
    Location:
    12 E; 12 55.92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105651611..105669317)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105685352..105703058)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene bradykinin receptor, beta 1 Neighboring gene autophagy related 2B Neighboring gene STARR-seq mESC enhancer starr_33186 Neighboring gene STARR-seq mESC enhancer starr_33187 Neighboring gene STARR-positive B cell enhancer ABC_E5352 Neighboring gene adenylate kinase 7 Neighboring gene STARR-seq mESC enhancer starr_33192 Neighboring gene STARR-seq mESC enhancer starr_33193 Neighboring gene STARR-seq mESC enhancer starr_33194 Neighboring gene poly (A) polymerase alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20789

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    GSK3B-interacting protein
    Names
    GSK3-beta interaction protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178613.3NP_848728.2  GSK3B-interacting protein

      See identical proteins and their annotated locations for NP_848728.2

      Status: VALIDATED

      Source sequence(s)
      AC158526, AK017049
      Consensus CDS
      CCDS49161.1
      UniProtKB/Swiss-Prot
      Q8BGR8, Q8CDW3, Q8K2G9
      UniProtKB/TrEMBL
      Q3TBR1
      Related
      ENSMUSP00000057939.6, ENSMUST00000051934.7
      Conserved Domains (1) summary
      pfam05303
      Location:38138
      DUF727; Protein of unknown function (DUF727)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      105651611..105669317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)