Ddx1 DEAD box helicase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ddx1provided by MGI
Official Full Name: DEAD box helicase 1provided by MGI
Primary source: MGI:MGI:2144727
See related: Ensembl:ENSMUSG00000037149 AllianceGenome:MGI:2144727
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DBP-RB
Summary: Enables double-stranded RNA binding activity. Involved in positive regulation of canonical NF-kappaB signal transduction and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytoplasmic stress granule; cytosol; and mitochondrion. Is expressed in several structures, including 1st branchial arch; blastocyst; central nervous system; early embryo; and genitourinary system. Orthologous to human DDX1 (DEAD-box helicase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in CNS E11.5 (RPKM 45.1), CNS E14 (RPKM 31.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 6.4 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (13269308..13299175, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (13219307..13249174, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the Lysosomal Degradation of DDX1.
Title: CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the Lysosomal Degradation of DDX1.
The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops).
Title: The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops).
DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos.
Title: DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos.
A comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation.
Title: A comprehensive RNA editome reveals that edited Azin1 partners with DDX1 to enable hematopoietic stem cell differentiation.
A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing.
Title: A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing.
DDX1 is an essential protein in embryonic development
Title: Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout.
DDX1-mediated repression of insulin translation worsens the situation of insulin resistance and contributes to the elevation of blood glucose levels in obese animals
Title: RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation.
we show that the transcript levels of an RNA helicase, Ddx1, regulates strain differences in the amount of nitric oxide produced by macrophage after stimulation with interferon gamma and tumor necrosis factor.
Title: Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection.
Coronavirus N phosphorylation by GSK-3 allows recruitment of the RNA helicase DDX1, which facilitates template readthrough and enables longer viral positive-sense single-stranded genomic RNA synthesis.
Title: Nucleocapsid phosphorylation and RNA helicase DDX1 recruitment enables coronavirus transition from discontinuous to continuous transcription.
DDX1 promotes the expression of a subset of microRNAs. Knockdown of DDX1 promotes ovarian tumor invasion and metastasis.
Title: The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA/RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables DNA/RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	ISO Inferred from Sequence Orthology more info
enables nuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables poly(A) binding	ISO Inferred from Sequence Orthology more info
enables poly(A) binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
involved_in DNA duplex unwinding	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in nucleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myeloid dendritic cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to exogenous dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA splicing, via endonucleolytic cleavage and ligation	ISO Inferred from Sequence Orthology more info
involved_in tRNA splicing, via endonucleolytic cleavage and ligation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cleavage body	ISO Inferred from Sequence Orthology more info
located_in cleavage body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of tRNA-splicing ligase complex	ISO Inferred from Sequence Orthology more info
part_of tRNA-splicing ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DDX1

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1

NP_598801.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134040.1 → NP_598801.1 ATP-dependent RNA helicase DDX1

See identical proteins and their annotated locations for NP_598801.1

Status: PROVISIONAL

Source sequence(s)

BC010624

Consensus CDS

CCDS25819.1

UniProtKB/Swiss-Prot

Q3TU41, Q91VR5

UniProtKB/TrEMBL

Q3V1Z7, Q922B8

Related

ENSMUSP00000065987.9, ENSMUST00000071103.10

Conserved Domains (4) summary

COG0513
Location:284 → 624

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

pfam00271
Location:493 → 609

Helicase_C; Helicase conserved C-terminal domain

cd12873
Location:93 → 245

SPRY_DDX1; SPRY domain associated with DEAD box gene DDX1

cl21455
Location:284 → 426

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases