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    Srpk3 serine/arginine-rich protein specific kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 56504, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Srpk3provided by MGI
    Official Full Name
    serine/arginine-rich protein specific kinase 3provided by MGI
    Primary source
    MGI:MGI:1891338
    See related
    Ensembl:ENSMUSG00000002007 AllianceGenome:MGI:1891338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mssk1; Stk23
    Summary
    Enables protein serine/threonine kinase activity. Involved in muscle tissue development. Acts upstream of or within protein phosphorylation and skeletal muscle tissue development. Predicted to be active in cytoplasm and nucleus. Is expressed in tail mesenchyme; tongue; and vertebral axis musculature. Orthologous to human SRPK3 (SRSF protein kinase 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in spleen adult (RPKM 23.8), heart adult (RPKM 14.3) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srpk3 in Genome Data Viewer
    Location:
    X A7.3; X 37.41 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72818011..72822531)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73772608..73778925)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25226 Neighboring gene plexin B3 Neighboring gene isocitrate dehydrogenase 3 (NAD+), gamma Neighboring gene STARR-positive B cell enhancer ABC_E11049 Neighboring gene signal sequence receptor, delta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model. Seo MH, et al. Mol Neurobiol, 2023 Feb. PMID 36369636
    2. Srpk3 Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson's Disease Mice. Seo MH, et al. Int J Mol Sci, 2021 Aug 29. PMID 34502283, Free PMC Article
    3. Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Potthoff MJ, et al. Mol Cell Biol, 2007 Dec. PMID 17875930, Free PMC Article
    4. Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Davie JK, et al. Dev Biol, 2007 Nov 15. PMID 17904117
    5. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Nakagawa O, et al. Genes Dev, 2005 Sep 1. PMID 16140986, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model.
      Title: Association Between Decreased Srpk3 Expression and Increased Substantia Nigra Alpha-Synuclein Level in an MPTP-Induced Parkinson's Disease Mouse Model.
    2. Srpk3 Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson's Disease Mice.
      Title: Srpk3 Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson's Disease Mice.
    3. normal muscle growth and homeostasis require MEF2-dependent signaling by Srpk3
      Title: Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SRSF protein kinase 3
    Names
    SR-protein-specific kinase 3
    muscle-specific serine kinase 1
    serine/threonine kinase 23, muscle-specific serine kinase 1 70
    serine/threonine-protein kinase 23
    serine/threonine-protein kinase SRPK3
    NP_001413247.1
    NP_062658.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426318.1 → NP_001413247.1  SRSF protein kinase 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672094

    2. NM_019684.2 → NP_062658.1  SRSF protein kinase 3 isoform 2

      See identical proteins and their annotated locations for NP_062658.1

      Status: VALIDATED

      Source sequence(s)
      AF043288, BY243709
      Consensus CDS
      CCDS30211.1
      UniProtKB/Swiss-Prot
      Q9Z0G2
      UniProtKB/TrEMBL
      Q0VAW8, Q684J2
      Related
      ENSMUSP00000002081.6, ENSMUST00000002081.6
      Conserved Domains (2) summary
      smart00220
      Location:78 → 563
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14218
      Location:67 → 563
      STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72818011..72822531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0G2.1 GenPept UniProtKB/Swiss-Prot:Q9Z0G2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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