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    Rnpep arginyl aminopeptidase (aminopeptidase B) [ Mus musculus (house mouse) ]

    Gene ID: 215615, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Rnpepprovided by MGI
    Official Full Name
    arginyl aminopeptidase (aminopeptidase B)provided by MGI
    Primary source
    MGI:MGI:2384902
    See related
    Ensembl:ENSMUSG00000041926 AllianceGenome:MGI:2384902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Predicted to be involved in negative regulation of blood pressure and protein processing. Predicted to be located in external side of plasma membrane; extracellular region; and secretory granule. Predicted to be active in extracellular space. Is expressed in central nervous system and sensory organ. Orthologous to human RNPEP (arginyl aminopeptidase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 45.6), large intestine adult (RPKM 34.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnpep in Genome Data Viewer
    Location:
    1 E4; 1 58.43 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135190447..135211765, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135262699..135284423, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nucleosome assembly protein 1-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02360 Neighboring gene E74-like factor 3 Neighboring gene myeloma-overexpressed gene 2 protein homolog Neighboring gene translocase of inner mitochondrial membrane 17a Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:137210226-137210413

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B. Fontés G, et al. Endocrinology, 2005 Feb. PMID 15539558
    2. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Kathiresan T, et al. Mol Cell Proteomics, 2009 Aug. PMID 19423573, Free PMC Article
    3. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miniglucagon-generating endopeptidase is composed of NRDc and aminopeptidase B acting sequentially
      Title: Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29229

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cobalt ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aminopeptidase B
    Names
    AP-B
    arginine aminopeptidase
    cytosol aminopeptidase IV
    NP_001153096.1
    NP_663392.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159624.2 → NP_001153096.1  aminopeptidase B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130277
      Consensus CDS
      CCDS48373.1
      UniProtKB/TrEMBL
      E9PYF1, Q8BMH2
      Related
      ENSMUSP00000073962.8, ENSMUST00000074357.8
      Conserved Domains (2) summary
      cd09599
      Location:24 → 445
      M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
      pfam09127
      Location:491 → 606
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    2. NM_145417.4 → NP_663392.2  aminopeptidase B isoform 1

      See identical proteins and their annotated locations for NP_663392.2

      Status: VALIDATED

      Source sequence(s)
      AC130277
      Consensus CDS
      CCDS15317.1
      UniProtKB/Swiss-Prot
      Q3TX27, Q8VCT3
      UniProtKB/TrEMBL
      Q8BMH2
      Related
      ENSMUSP00000076564.8, ENSMUST00000077340.14
      Conserved Domains (3) summary
      cd09599
      Location:24 → 484
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:24 → 634
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:504 → 644
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    RNA

    1. NR_185276.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130277

    2. NR_185277.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130277

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135190447..135211765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCT3.2 GenPept UniProtKB/Swiss-Prot:Q8VCT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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