Stk19 serine/threonine kinase 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stk19provided by RGD
Official Full Name: serine/threonine kinase 19provided by RGD
Primary source: RGD:1359601
See related: EnsemblRapid:ENSRNOG00000048929 AllianceGenome:RGD:1359601
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in positive regulation of Ras protein signal transduction. Predicted to be located in cytoplasm and nuclear speck. Orthologous to human STK19 (serine/threonine kinase 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 89.4), Lung (RPKM 37.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4000216..4009743)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3995590..4005117)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (4317440..4517128, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_5887-5888:991939775:1 (e-PCR)
- UniSTS:231180

MARC_5887-5888:997299395:1 (e-PCR)
- UniSTS:231180

D20Yum62 (e-PCR)
- UniSTS:526103

D20Yum58 (e-PCR)
- UniSTS:526104

D20Yum61 (e-PCR)
- UniSTS:526110

RH139384 (e-PCR)
- UniSTS:221470

RH133069 (e-PCR)
- UniSTS:216352

D20Yum63 (e-PCR)
- UniSTS:526117

D20Yum59 (e-PCR)
- UniSTS:526124

AI013941 (e-PCR)
- UniSTS:250418

D20Yum60 (e-PCR)
- UniSTS:526131

RH94616 (e-PCR)
- UniSTS:119864

UniSTS:465467 (e-PCR)
- UniSTS:465467

Notch4 (e-PCR), detects polymorphism
- UniSTS:465467

UniSTS:237630 (e-PCR)
- UniSTS:237630

BF405332 (e-PCR)
- UniSTS:247884

RH140482 (e-PCR)
- UniSTS:222554

BE115494 (e-PCR)
- UniSTS:248163

PMC162222P1 (e-PCR)
- UniSTS:271463

BI284306 (e-PCR)
- UniSTS:244079

RH135211 (e-PCR)
- UniSTS:218488

RH131882 (e-PCR)
- UniSTS:215165

RH124332 (e-PCR)
- UniSTS:161154

BE113482 (e-PCR)
- UniSTS:246670

AI453961 (e-PCR)
- UniSTS:226220

AU026365 (e-PCR)
- UniSTS:114352

RH133750 (e-PCR)
- UniSTS:217033

RH137557 (e-PCR)
- UniSTS:217033

BF413235 (e-PCR)
- UniSTS:248523

RH138792 (e-PCR)
- UniSTS:220879

BE119939 (e-PCR)
- UniSTS:249306

BF390804 (e-PCR)
- UniSTS:249576

RH134814 (e-PCR)
- UniSTS:218092

AI176804 (e-PCR)
- UniSTS:250354

RH139089 (e-PCR)
- UniSTS:221175

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inactive serine/threonine-protein kinase 19

Names: serine/threonine-protein kinase 19

NP_001013215.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013197.2 → NP_001013215.2 inactive serine/threonine-protein kinase 19

Status: VALIDATED

Source sequence(s)

BC061571, CO398403

UniProtKB/TrEMBL

A0A8I5ZJ96, Q6P7Q3

Related

ENSRNOP00000076734.1, ENSRNOT00000072446.5

Conserved Domains (1) summary

pfam10494
Location:28 → 251

Stk19; Serine-threonine protein kinase 19