DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DYRK3provided by HGNC
Official Full Name: dual specificity tyrosine phosphorylation regulated kinase 3provided by HGNC
Primary source: HGNC:HGNC:3094
See related: Ensembl:ENSG00000143479 MIM:603497; AllianceGenome:HGNC:3094
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RED; REDK; DYRK5; hYAK3-2
Summary: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 8.5), gall bladder (RPKM 5.7) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (206635536..206655158)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (205899707..205919328)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (206808881..206828503)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dual-specificity kinase DYRK3 phosphorylates p62 at the Thr-269 residue and promotes melanoma progression.
Title: Dual-specificity kinase DYRK3 phosphorylates p62 at the Thr-269 residue and promotes melanoma progression.
Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone.
Title: Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone.
DYRK3 contributes to differentiation and hypoxic control in neuroblastoma.
Title: DYRK3 contributes to differentiation and hypoxic control in neuroblastoma.
Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview.
Title: Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview.
Dual Specificity Kinase DYRK3 Promotes Aggressiveness of Glioblastoma by Altering Mitochondrial Morphology and Function.
Title: Dual Specificity Kinase DYRK3 Promotes Aggressiveness of Glioblastoma by Altering Mitochondrial Morphology and Function.
Study shows that the auto-phosphorylation of S350 of DYRK3 stabilizes the protein and positively regulates the functional activity. The S350 residue is located between N-lobe and C-lobe and its auto-phosphorylation mediates hydrogen bond interactions with many nearby residues from C-lobe domain and alphaC-helix to stabilize overall structure.
Title: Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylation.
a mechanism in which the dilution of phase-separating proteins during nuclear-envelope breakdown and the DYRK3-dependent degree of their solubility combine to allow cells to dissolve and condense several membraneless organelles during mitosis
Title: Kinase-controlled phase transition of membraneless organelles in mitosis.
Study identified the dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) as a protein with the ability to condense P-granule-like speckles in the cytosol and to prevent stress granule dissolution via its N-terminal domain when it is in a kinase-inactive form.
Title: Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling.
the lipid raft-dependent endocytosis process mediates C. neoformans internalization into HBMEC and the CD44 protein of the hosts, cytoskeleton, and intracellular kinase-DYRK3 are involved in this process
Title: Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3).
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
Title: DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH98487 (e-PCR)
- UniSTS:89927

DYRK3__4798 (e-PCR)
- UniSTS:471424

G34856 (e-PCR)
- UniSTS:66750

NIB1752 (e-PCR)
- UniSTS:20183

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in nuclear speck organization	IDA Inferred from Direct Assay more info	PubMed
involved_in organelle disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell cycle G2/M phase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress granule disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress granule disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in stress granule disassembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 3

Names: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5; protein kinase Dyrk3; regulatory erythroid kinase

NP_001004023.1

EC 2.7.12.1

NP_003573.2

EC 2.7.12.1

XP_005273372.1

EC 2.7.12.1

XP_011508363.1

EC 2.7.12.1

XP_047288070.1

EC 2.7.12.1

XP_047288071.1

EC 2.7.12.1

XP_047288074.1

EC 2.7.12.1

XP_054195170.1

EC 2.7.12.1

XP_054195171.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004023.3 → NP_001004023.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b

See identical proteins and their annotated locations for NP_001004023.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional segment in the coding region compared to variant 1. The resulting isoform (b), also known as the isoform RED-S, contains a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AL591846, AU126055, BC015501, Y12735

Consensus CDS

CCDS31000.1

UniProtKB/TrEMBL

A8K574

Related

ENSP00000356075.3, ENST00000367108.7

Conserved Domains (2) summary

smart00220
Location:189 → 502

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14224
Location:123 → 502

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
NM_003582.4 → NP_003573.2 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a

See identical proteins and their annotated locations for NP_003573.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript, but encodes the longer isoform (a), also known as the RED-L isoform.

Source sequence(s)

AL591846, AU126055, BC015501, Y12735

Consensus CDS

CCDS30999.1

UniProtKB/Swiss-Prot

D3DT79, O43781, Q7Z752, Q9HBY6, Q9HBY7

UniProtKB/TrEMBL

A8K574

Related

ENSP00000356076.2, ENST00000367109.8

Conserved Domains (2) summary

smart00220
Location:209 → 522

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14224
Location:143 → 522

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

206635536..206655158

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047432118.1 → XP_047288074.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2
XM_005273315.5 → XP_005273372.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

See identical proteins and their annotated locations for XP_005273372.1

UniProtKB/TrEMBL

A8K574

Conserved Domains (2) summary

smart00220
Location:189 → 502

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14224
Location:123 → 502

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
XM_047432114.1 → XP_047288070.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1
XM_047432115.1 → XP_047288071.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

Related

ENSP00000356073.1, ENST00000367106.1
XM_011510061.3 → XP_011508363.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2

UniProtKB/TrEMBL

B2R859

Conserved Domains (2) summary

smart00220
Location:174 → 487

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14224
Location:108 → 487

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

205899707..205919328

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054339195.1 → XP_054195170.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1
XM_054339196.1 → XP_054195171.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2