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    ZNF544 zinc finger protein 544 [ Homo sapiens (human) ]

    Gene ID: 27300, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF544provided by HGNC
    Official Full Name
    zinc finger protein 544provided by HGNC
    Primary source
    HGNC:HGNC:16759
    See related
    Ensembl:ENSG00000198131 AllianceGenome:HGNC:16759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.1), testis (RPKM 3.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF544 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58228914..58277455)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61325370..61373860)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58740280..58788821)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372479 Neighboring gene ribosomal protein S15a pseudogene 36 Neighboring gene zinc finger protein 436 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58740156-58740982 Neighboring gene ZNF8 divergent transcript Neighboring gene ZNF8-ERVK3-1 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15182 Neighboring gene zinc finger protein 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15183 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58816949-58817449 Neighboring gene Sharpr-MPRA regulatory region 7439 Neighboring gene endogenous retrovirus group K3 member 1 Neighboring gene uncharacterized LOC105372480

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Lasky-Su J, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Dec 5. PMID 18821565
    2. HENA, heterogeneous network-based data set for Alzheimer's disease. Sügis E, et al. Sci Data, 2019 Aug 14. PMID 31413325, Free PMC Article
    3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    4. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
    5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 544

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320767.2 → NP_001307696.1  zinc finger protein 544 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 and 21-13 all encode the same isoform (1).
      Source sequence(s)
      AC020915, AL833618, BC067271, DA193549, DA342047
      Consensus CDS
      CCDS12973.1
      UniProtKB/Swiss-Prot
      A8K6J1, Q6NX49, Q9UEX4
      Conserved Domains (4) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:406 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:370 → 391
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001320769.2 → NP_001307698.1  zinc finger protein 544 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 and 21-13 all encode the same isoform (1).
      Source sequence(s)
      AC020915, BC018980, DC310430
      Consensus CDS
      CCDS12973.1
      UniProtKB/Swiss-Prot
      A8K6J1, Q6NX49, Q9UEX4
      Conserved Domains (4) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:406 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:370 → 391
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001320770.2 → NP_001307699.1  zinc finger protein 544 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 4-6 all encode the same isoform (2).
      Source sequence(s)
      AK316446, AL833618, BC067271, DA193549
      Consensus CDS
      CCDS82413.1
      UniProtKB/TrEMBL
      J3KQC8
      Related
      ENSP00000472721.1, ENST00000600044.5
      Conserved Domains (5) summary
      smart00349
      Location:14 → 61
      KRAB; krueppel associated box
      COG5048
      Location:378 → 671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:466 → 486
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:450 → 475
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001320771.2 → NP_001307700.1  zinc finger protein 544 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 4-6 all encode the same isoform (2).
      Source sequence(s)
      AK296846, AL833618, BC067271, DA193549
      Consensus CDS
      CCDS82413.1
      UniProtKB/TrEMBL
      J3KQC8
      Related
      ENSP00000471684.1, ENST00000600220.5
      Conserved Domains (5) summary
      smart00349
      Location:14 → 61
      KRAB; krueppel associated box
      COG5048
      Location:378 → 671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:466 → 486
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:450 → 475
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001320773.2 → NP_001307702.1  zinc finger protein 544 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 4-6 all encode the same isoform (2).
      Source sequence(s)
      AC020915, AK296846, AL833618, BC018980, BC067271, DC310430
      Consensus CDS
      CCDS82413.1
      UniProtKB/TrEMBL
      J3KQC8
      Conserved Domains (5) summary
      smart00349
      Location:14 → 61
      KRAB; krueppel associated box
      COG5048
      Location:378 → 671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:466 → 486
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:450 → 475
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001320774.2 → NP_001307703.1  zinc finger protein 544 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1. Variants 7 and 24 both encode the same isoform (3).
      Source sequence(s)
      AC020915, BC018980, DC310430
      Conserved Domains (4) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:171 → 464
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:135 → 156
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001320776.2 → NP_001307705.1  zinc finger protein 544 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate start site, compared to variant 1. The encoded protein (isoform 4) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC020915, AK291656, BU626073, DA193549
      UniProtKB/Swiss-Prot
      Q6NX49
      Conserved Domains (3) summary
      smart00349
      Location:68 → 107
      KRAB; krueppel associated box
      pfam01352
      Location:68 → 107
      KRAB; KRAB box
      pfam13900
      Location:130 → 151
      GVQW; Putative domain of unknown function

    8. NM_001320777.2 → NP_001307706.1  zinc finger protein 544 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate start site, compared to variant 1. The encoded protein (isoform 5) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC020915, AL833618, BC067271, DA193549, DB200767
      UniProtKB/Swiss-Prot
      Q6NX49
      Conserved Domains (2) summary
      smart00349
      Location:68 → 107
      KRAB; krueppel associated box
      pfam01352
      Location:68 → 107
      KRAB; KRAB box

    9. NM_001320780.2 → NP_001307709.1  zinc finger protein 544 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) contains an alternate 3' terminal exon, compared to variant 1. It encodes a shorter isoform (6) which has a distinct C-terminus, compared to isoform 1. Variants 10, 25, and 26 all encode the same isoform (6).
      Source sequence(s)
      AC020915, AK291656, BU626073, DA193549
      UniProtKB/Swiss-Prot
      Q6NX49
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    10. NM_001320781.2 → NP_001307710.1  zinc finger protein 544 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate start site, compared to variant 1. The encoded protein (isoform 7) is shorter and has distinct N- and C-termini, compared to isoform 1. Variants 11 and 27 both encode the same isoform (7).
      Source sequence(s)
      AC020915, BC018980, DC310430
      Conserved Domains (1) summary
      smart00349
      Location:68 → 107
      KRAB; krueppel associated box

    11. NM_001320782.3 → NP_001307711.1  zinc finger protein 544 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) contains an alternate 3' terminal exon, compared to variant 1. It encodes a shorter isoform (8) which has a distinct C-terminus, compared to isoform 1. Variants 12, 29, 30, and 33 all encode the same isoform (8).
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS82411.1
      UniProtKB/TrEMBL
      M0QX86, M0QZM7
      Related
      ENSP00000470645.1, ENST00000596929.5
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    12. NM_001320783.2 → NP_001307712.1  zinc finger protein 544 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate start site, compared to variant 1. The encoded protein (isoform 9) is shorter and has distinct N- and C-termini, compared to isoform 1. Variants 13 and 28 both encode the same isoform (9).
      Source sequence(s)
      AC020915, AK291656, BU626073
      UniProtKB/Swiss-Prot
      Q6NX49
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    13. NM_001320785.2 → NP_001307714.1  zinc finger protein 544 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) uses alternate splice sites in the penultimate and 3' terminal exons, compared to variant 1. It encodes isoform 10 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 14-16 and 35 all encode the same isoform (10).
      Source sequence(s)
      AL833618, BC067271, DA193549, DB200767
      UniProtKB/TrEMBL
      A0A1B0GV72
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    14. NM_001320786.2 → NP_001307715.1  zinc finger protein 544 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR and uses alternate splice sites in the penultimate and 3' terminal exons, compared to variant 1. It encodes isoform 10 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 14-16 and 35 all encode the same isoform (10).
      Source sequence(s)
      AC020915, AL833618, BC067271, DA193549, DB200767
      UniProtKB/TrEMBL
      A0A1B0GV72
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    15. NM_001320787.2 → NP_001307716.1  zinc finger protein 544 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR and uses alternate splice sites in the penultimate and 3' terminal exons, compared to variant 1. It encodes isoform 10 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 14-16 and 35 all encode the same isoform (10).
      Source sequence(s)
      AC020915, BC018980, DC310430
      UniProtKB/TrEMBL
      A0A1B0GV72
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    16. NM_001320788.2 → NP_001307717.1  zinc finger protein 544 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) uses an alternate splice site in the penultimate exon, compared to variant 1. It encodes isoform 11 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 17-20, 36, and 37 all encode the same isoform (11).
      Source sequence(s)
      AC020915, AL833618, DA193549
      Consensus CDS
      CCDS82412.1
      UniProtKB/TrEMBL
      A0A1B0GV72, M0R2F0
      Related
      ENSP00000471480.1, ENST00000599227.5
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    17. NM_001320789.2 → NP_001307718.1  zinc finger protein 544 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR and uses an alternate splice site in the penultimate exon, compared to variant 1. It encodes isoform 11 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 17-20, 36, and 37 all encode the same isoform (11).
      Source sequence(s)
      AC020915, BC018980, DC310430
      Consensus CDS
      CCDS82412.1
      UniProtKB/TrEMBL
      A0A1B0GV72, M0R2F0
      Related
      ENSP00000472512.1, ENST00000596825.5
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    18. NM_001320791.2 → NP_001307720.1  zinc finger protein 544 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR and uses an alternate splice site in the penultimate exon, compared to variant 1. It encodes isoform 11 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 17-20, 36, and 37 all encode the same isoform (11).
      Source sequence(s)
      AL833618, BC067271, DA193549, DA342047
      Consensus CDS
      CCDS82412.1
      UniProtKB/TrEMBL
      A0A1B0GV72, M0R2F0
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    19. NM_001320792.2 → NP_001307721.1  zinc finger protein 544 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) differs in the 5' UTR and uses an alternate splice site in the penultimate exon, compared to variant 1. It encodes isoform 11 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 17-20, 36, and 37 all encode the same isoform (11).
      Source sequence(s)
      AC020915, AL833618, DA193549
      Consensus CDS
      CCDS82412.1
      UniProtKB/TrEMBL
      A0A1B0GV72, M0R2F0
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    20. NM_001387390.1 → NP_001374319.1  zinc finger protein 544 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variants 1-3, 22, and 23, encodes isoform 1.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS12973.1
      UniProtKB/Swiss-Prot
      A8K6J1, Q6NX49, Q9UEX4
      Related
      ENSP00000269829.4, ENST00000269829.5
      Conserved Domains (4) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:406 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:370 → 391
      zf-H2C2_2; Zinc-finger double domain

    21. NM_001387391.1 → NP_001374320.1  zinc finger protein 544 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22), as well as variants 1-3, 21, and 23, encodes isoform 1.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS12973.1
      UniProtKB/Swiss-Prot
      A8K6J1, Q6NX49, Q9UEX4
      Conserved Domains (4) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:406 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:370 → 391
      zf-H2C2_2; Zinc-finger double domain

    22. NM_001387392.1 → NP_001374321.1  zinc finger protein 544 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variants 1-3, 21, and 22, encodes isoform 1.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS12973.1
      UniProtKB/Swiss-Prot
      A8K6J1, Q6NX49, Q9UEX4
      Conserved Domains (4) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:406 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:370 → 391
      zf-H2C2_2; Zinc-finger double domain

    23. NM_001387393.1 → NP_001374322.1  zinc finger protein 544 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24), as well as variant 7, encodes isoform 3.
      Source sequence(s)
      AC020915
      Conserved Domains (4) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:171 → 464
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:135 → 156
      zf-H2C2_2; Zinc-finger double domain

    24. NM_001387394.1 → NP_001374323.1  zinc finger protein 544 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25), as well as variants 10 and 26, encodes isoform 6.
      Source sequence(s)
      AC020915
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    25. NM_001387395.1 → NP_001374324.1  zinc finger protein 544 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26), as well as variants 10 and 25, encodes isoform 6.
      Source sequence(s)
      AC020915
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    26. NM_001387396.1 → NP_001374325.1  zinc finger protein 544 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (27), as well as variant 11, encodes isoform 7.
      Source sequence(s)
      AC020915
      Conserved Domains (1) summary
      smart00349
      Location:68 → 107
      KRAB; krueppel associated box

    27. NM_001387397.1 → NP_001374326.1  zinc finger protein 544 isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28), as well as variant 13, encodes isoform 9.
      Source sequence(s)
      AC020915
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    28. NM_001387398.1 → NP_001374327.1  zinc finger protein 544 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (29), as well as variants 12, 30, and 33, encodes isoform 8.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS82411.1
      UniProtKB/TrEMBL
      M0QX86, M0QZM7
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    29. NM_001387399.1 → NP_001374328.1  zinc finger protein 544 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (30), as well as variants 12, 29, and 33, encodes isoform 8.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS82411.1
      UniProtKB/TrEMBL
      M0QX86, M0QZM7
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    30. NM_001387400.1 → NP_001374329.1  zinc finger protein 544 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (33), as well as variants 12, 29, and 30, encodes isoform 8.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS82411.1
      UniProtKB/TrEMBL
      M0QX86, M0QZM7
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    31. NM_001387401.1 → NP_001374330.1  zinc finger protein 544 isoform 26

      Status: VALIDATED

      Description
      Transcript Variant: This variant (31), as well as variants 32 and 34, encodes isoform 26.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    32. NM_001387402.1 → NP_001374331.1  zinc finger protein 544 isoform 26

      Status: VALIDATED

      Description
      Transcript Variant: This variant (32), as well as variants 31 and 34, encodes isoform 26.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    33. NM_001387403.1 → NP_001374332.1  zinc finger protein 544 isoform 26

      Status: VALIDATED

      Description
      Transcript Variant: This variant (34), as well as variants 31 and 32, encodes isoform 26.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    34. NM_001387407.1 → NP_001374336.1  zinc finger protein 544 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (35), as well as variants 14-16, encodes isoform 10.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      A0A1B0GV72
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    35. NM_001387408.1 → NP_001374337.1  zinc finger protein 544 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (36), as well as variants 17-20 and 37, encodes isoform 11.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS82412.1
      UniProtKB/TrEMBL
      A0A1B0GV72, M0R2F0
      Related
      ENSP00000498814.1, ENST00000652201.1
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    36. NM_001387409.1 → NP_001374338.1  zinc finger protein 544 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (37), as well as variants 17-20 and 36, encodes isoform 11.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS82412.1
      UniProtKB/TrEMBL
      A0A1B0GV72, M0R2F0
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    37. NM_001387410.1 → NP_001374339.1  zinc finger protein 544 isoform 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (38) encodes the longest isoform (12). Variants 38 and 39 both encode the same isoform (12).
      Source sequence(s)
      AC020915
      Conserved Domains (4) summary
      smart00349
      Location:68 → 127
      KRAB; krueppel associated box
      COG5048
      Location:460 → 753
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:548 → 568
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:424 → 445
      zf-H2C2_2; Zinc-finger double domain

    38. NM_001387413.1 → NP_001374342.1  zinc finger protein 544 isoform 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (39) encodes the longest isoform (12). Variants 38 and 39 both encode the same isoform (12).
      Source sequence(s)
      AC020915
      Conserved Domains (4) summary
      smart00349
      Location:68 → 127
      KRAB; krueppel associated box
      COG5048
      Location:460 → 753
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:548 → 568
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:424 → 445
      zf-H2C2_2; Zinc-finger double domain

    39. NM_001387415.1 → NP_001374344.1  zinc finger protein 544 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC020915
      Conserved Domains (4) summary
      smart00349
      Location:1 → 53
      KRAB; krueppel associated box
      COG5048
      Location:386 → 679
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:474 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:350 → 371
      zf-H2C2_2; Zinc-finger double domain

    40. NM_001387416.1 → NP_001374345.1  zinc finger protein 544 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC020915
      Conserved Domains (1) summary
      smart00349
      Location:68 → 127
      KRAB; krueppel associated box

    41. NM_001387417.1 → NP_001374346.1  zinc finger protein 544 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC020915
      Conserved Domains (1) summary
      smart00349
      Location:68 → 127
      KRAB; krueppel associated box

    42. NM_001387418.1 → NP_001374347.1  zinc finger protein 544 isoform 16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (43), as well as variant 44, encodes isoform 16.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS92700.1
      UniProtKB/TrEMBL
      M0QZY0
      Related
      ENSP00000470843.1, ENST00000595981.5
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    43. NM_001387419.1 → NP_001374348.1  zinc finger protein 544 isoform 16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (44), as well as variant 43, encodes isoform 16.
      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS92700.1
      UniProtKB/TrEMBL
      M0QZY0
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    44. NM_001387420.1 → NP_001374349.1  zinc finger protein 544 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC020915
      Conserved Domains (1) summary
      smart00349
      Location:68 → 107
      KRAB; krueppel associated box

    45. NM_001387421.1 → NP_001374350.1  zinc finger protein 544 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC020915
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    46. NM_001387422.1 → NP_001374351.1  zinc finger protein 544 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    47. NM_001387423.1 → NP_001374352.1  zinc finger protein 544 isoform 20

      Status: VALIDATED

      Description
      Transcript Variant: This variant (48), as well as variants 49 and 50, encodes isoform 20.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    48. NM_001387424.1 → NP_001374353.1  zinc finger protein 544 isoform 20

      Status: VALIDATED

      Description
      Transcript Variant: This variant (49), as well as variants 48 and 50, encodes isoform 20.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    49. NM_001387425.1 → NP_001374354.1  zinc finger protein 544 isoform 20

      Status: VALIDATED

      Description
      Transcript Variant: This variant (50), as well as variants 48 and 49, encodes isoform 20.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    50. NM_001387426.1 → NP_001374355.1  zinc finger protein 544 isoform 21

      Status: VALIDATED

      Description
      Transcript Variant: This variant (51), as well as variants 52 and 53, encodes isoform 21.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      A0A1B0GV72
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    51. NM_001387427.1 → NP_001374356.1  zinc finger protein 544 isoform 21

      Status: VALIDATED

      Description
      Transcript Variant: This variant (52), as well as variants 51 and 53, encodes isoform 21.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      A0A1B0GV72
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    52. NM_001387428.1 → NP_001374357.1  zinc finger protein 544 isoform 21

      Status: VALIDATED

      Description
      Transcript Variant: This variant (53), as well as variants 51 and 52, encodes isoform 21.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      A0A1B0GV72
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    53. NM_001387429.1 → NP_001374358.1  zinc finger protein 544 isoform 22

      Status: VALIDATED

      Description
      Transcript Variant: This variant (54), as well as variants 55-57, encodes isoform 22.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    54. NM_001387431.1 → NP_001374360.1  zinc finger protein 544 isoform 22

      Status: VALIDATED

      Description
      Transcript Variant: This variant (55), as well as variants 54, 56, and 57, encodes isoform 22.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    55. NM_001387432.1 → NP_001374361.1  zinc finger protein 544 isoform 22

      Status: VALIDATED

      Description
      Transcript Variant: This variant (56), as well as variants 54, 55, and 57, encodes isoform 22.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Related
      ENSP00000468975.1, ENST00000597240.5
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    56. NM_001387433.1 → NP_001374362.1  zinc finger protein 544 isoform 22

      Status: VALIDATED

      Description
      Transcript Variant: This variant (57), as well as variants 54-56, encodes isoform 22.
      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      M0QX86
      Conserved Domains (1) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box

    57. NM_001387434.1 → NP_001374363.1  zinc finger protein 544 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC020915
      Consensus CDS
      CCDS92701.1
      UniProtKB/TrEMBL
      A0A1B0GV72, M0R0U7
      Related
      ENSP00000471452.1, ENST00000596677.5
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    58. NM_001387435.1 → NP_001374364.1  zinc finger protein 544 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      A0A1B0GV72
      Conserved Domains (1) summary
      smart00349
      Location:14 → 53
      KRAB; krueppel associated box

    59. NM_001387436.1 → NP_001374365.1  zinc finger protein 544 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC020915
      UniProtKB/TrEMBL
      A0A1B0GVN2
      Conserved Domains (1) summary
      cl02581
      Location:14 → 42
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    60. NM_001412174.1 → NP_001399103.1  zinc finger protein 544 isoform 27

      Status: VALIDATED

      Description
      Transcript Variant: This variant (60) represents an alternate allele of variant 46 on T2T-CHM13v2.0 assembly. It contains a frameshift in the 3' CDS compared to variant 46, and encodes isoform 26, which has a shorter and different C-terminus compared to isoform 18.
      Source sequence(s)
      CP068259

    61. NM_014480.4 → NP_055295.2  zinc finger protein 544 isoform 1

      See identical proteins and their annotated locations for NP_055295.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1-3 and 21-23 all encode the same isoform (1).
      Source sequence(s)
      AK291656, AL833618, BC067271, DA193549
      Consensus CDS
      CCDS12973.1
      UniProtKB/Swiss-Prot
      A8K6J1, Q6NX49, Q9UEX4
      Related
      ENSP00000510489.1, ENST00000687789.1
      Conserved Domains (4) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:406 → 699
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:494 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:370 → 391
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58228914..58277455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61325370..61373860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NX49.1 GenPept UniProtKB/Swiss-Prot:Q6NX49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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