Ndufaf4 NADH:ubiquinone oxidoreductase complex assembly factor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndufaf4provided by RGD
Official Full Name: NADH:ubiquinone oxidoreductase complex assembly factor 4provided by RGD
Primary source: RGD:735162
See related: AllianceGenome:RGD:735162
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hrpap20
Summary: Predicted to enable calmodulin binding activity. Involved in negative regulation of apoptotic process and positive regulation of cell population proliferation. Predicted to be located in cytosol and mitochondrial membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 15. Orthologous to human NDUFAF4 (NADH:ubiquinone oxidoreductase complex assembly factor 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Heart (RPKM 288.8), Muscle (RPKM 196.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (43401795..43406967)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (38605169..38610341)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (39251370..39256542)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NADH dehydrogenase complex assembly	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex I assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

Names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4; NADH dehydrogenase (ubiquinone) complex I, assembly factor 4; hormone-regulated proliferation associated protein 20; hormone-regulated proliferation-associated 20 kDa protein; hormone-regulated proliferation-associated protein of 20 kDa homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198783.2 → NP_942078.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

See identical proteins and their annotated locations for NP_942078.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9NQR8

UniProtKB/TrEMBL

A0A8L2Q4K9, A6IIG9

Conserved Domains (1) summary

pfam06784
Location:2 → 166

UPF0240; Uncharacterized protein family (UPF0240)