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    Fbxl9 F-box and leucine-rich repeat protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 234684, updated on 17-Aug-2024

    Summary

    Official Symbol
    Fbxl9provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 9provided by MGI
    Primary source
    MGI:MGI:2443262
    See related
    Ensembl:ENSMUSG00000041679 AllianceGenome:MGI:2443262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBL9; Lrrc29; A630024J02Rik
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in adrenal gland; brain; gonad; metanephros; and spleen. Orthologous to human LRRC29 (leucine rich repeat containing 29). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 48.5), liver E14.5 (RPKM 7.9) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fbxl9 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106038972..106052952, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105312340..105326320, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107822735-107822970 Neighboring gene E2F transcription factor 4 Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328 Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene transmembrane protein 208 Neighboring gene formin homology 2 domain containing 1 Neighboring gene predicted gene, 46049

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 29
    Names
    leucine rich repeat containing 29

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368408.1NP_001355337.1  leucine-rich repeat-containing protein 29 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124584
      Consensus CDS
      CCDS90448.1
      UniProtKB/TrEMBL
      A0A1B0GQY9
      Related
      ENSMUSP00000147309.2, ENSMUST00000210412.2
      Conserved Domains (4) summary
      cd09293
      Location:240428
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:280305
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:338
      F-box-like
      cl39015
      Location:118360
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. NM_001368409.1NP_001355338.1  leucine-rich repeat-containing protein 29 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124584
      UniProtKB/TrEMBL
      Q3UG51
      Conserved Domains (4) summary
      smart00256
      Location:538
      FBOX; A Receptor for Ubiquitination Targets
      sd00034
      Location:254279
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl28166
      Location:240444
      AMN1; Antagonist of mitotic exit network protein 1
      cl29113
      Location:118360
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. NM_177449.4NP_803232.2  leucine-rich repeat-containing protein 29 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124584
      Consensus CDS
      CCDS57641.1
      UniProtKB/TrEMBL
      F6SF53
      Related
      ENSMUSP00000063248.8, ENSMUST00000070508.8
      Conserved Domains (2) summary
      cd09293
      Location:57131
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:2670
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106038972..106052952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530897.3XP_006530960.1  leucine-rich repeat-containing protein 29 isoform X2

      Conserved Domains (2) summary
      cd09293
      Location:140254
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:2652
      LRR_AMN1; leucine-rich repeat [structural motif]
    2. XM_006530893.5XP_006530956.1  leucine-rich repeat-containing protein 29 isoform X1

      See identical proteins and their annotated locations for XP_006530956.1

      UniProtKB/TrEMBL
      A0A1B0GQY9
      Conserved Domains (4) summary
      cd09293
      Location:240428
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:280305
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:338
      F-box-like
      cl39015
      Location:118360
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_036153969.1XP_036009862.1  leucine-rich repeat-containing protein 29 isoform X2

      Conserved Domains (2) summary
      cd09293
      Location:140254
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:2652
      LRR_AMN1; leucine-rich repeat [structural motif]
    4. XM_030243502.1XP_030099362.1  leucine-rich repeat-containing protein 29 isoform X2

      Conserved Domains (2) summary
      cd09293
      Location:140254
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:2652
      LRR_AMN1; leucine-rich repeat [structural motif]