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    Adam1a a disintegrin and metallopeptidase domain 1a [ Mus musculus (house mouse) ]

    Gene ID: 280668, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Adam1aprovided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 1aprovided by MGI
    Primary source
    MGI:MGI:2429504
    See related
    Ensembl:ENSMUSG00000072647 AllianceGenome:MGI:2429504
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftna; Adam1
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in membrane raft. Orthologous to human ADAM1A (ADAM metallopeptidase domain 1A (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Adam1a in Genome Data Viewer
    Location:
    5 F; 5 61.84 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121656667..121659758, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121518604..121521695, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 116 Neighboring gene STARR-positive B cell enhancer ABC_E4785 Neighboring gene mitogen-activated protein kinase 3 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene STARR-seq mESC enhancer starr_14259 Neighboring gene STARR-positive B cell enhancer ABC_E9092 Neighboring gene STARR-positive B cell enhancer ABC_E11301 Neighboring gene aldehyde dehydrogenase 2, mitochondrial Neighboring gene STARR-seq mESC enhancer starr_14260

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the binding of recombinant mouse sperm fertilin alpha subunit to mouse eggs: evidence for function as a cell adhesion molecule in sperm-egg binding. Evans JP, et al. Dev Biol, 1997 Jul 1. PMID 9224677
    2. Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm. Kim E, et al. Biochem Biophys Res Commun, 2003 May 2. PMID 12711316
    3. The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin alpha) gene, are localized on mouse chromosome 5. Nishimura H, et al. Gene, 2002 May 29. PMID 12095680
    4. Roles of the disintegrin domains of mouse fertilins alpha and beta in fertilization. Evans JP, et al. Biol Reprod, 1998 Jul. PMID 9675005
    5. Genomic organization of the mouse fertilin beta gene that encodes an ADAM family protein active in sperm-egg fusion. Cho C, et al. Dev Genet, 1997. PMID 9254906

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Localization of ADAM1a in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
      Title: Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm.
    2. ADAM1a/ADAM2 Fertilin complex has roles in expression of ADAM3 on the cell surface of mouse sperm
      Title: Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 1a
    Names
    ADAM 1a
    PH-30 alpha
    a disintegrin and metalloproteinase domain 1a (fertilin alpha)
    fertilin alpha
    fertilin subunit alpha-a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172126.2 → NP_742124.2  disintegrin and metalloproteinase domain-containing protein 1a precursor

      See identical proteins and their annotated locations for NP_742124.2

      Status: PROVISIONAL

      Source sequence(s)
      BC052093
      Consensus CDS
      CCDS19637.1
      UniProtKB/Swiss-Prot
      Q60617, Q60813, Q80WR7, Q8R533
      UniProtKB/TrEMBL
      Q3V0B1, Q3V0H1
      Related
      ENSMUSP00000098320.5, ENSMUST00000100757.6
      Conserved Domains (5) summary
      smart00050
      Location:447 → 519
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:521 → 657
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:235 → 427
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01421
      Location:235 → 429
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:95 → 190
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121656667..121659758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60813.3 GenPept UniProtKB/Swiss-Prot:Q60813

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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