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    PTPRD protein tyrosine phosphatase receptor type D [ Homo sapiens (human) ]

    Gene ID: 5789, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PTPRDprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Dprovided by HGNC
    Primary source
    HGNC:HGNC:9668
    See related
    Ensembl:ENSG00000153707 MIM:601598; AllianceGenome:HGNC:9668
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA; R-PTP-delta
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
    Expression
    Broad expression in brain (RPKM 18.0), kidney (RPKM 8.8) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PTPRD in Genome Data Viewer
    Location:
    9p24.1-p23
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (8314246..10613002, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (8320802..10622316, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (8314246..10613002, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:7799542-7800088 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:7879626-7880126 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:7880127-7880627 Neighboring gene uncharacterized LOC105375971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28213 Neighboring gene VISTA enhancer hs304 Neighboring gene distal membrane arm assembly component 1 Neighboring gene Sharpr-MPRA regulatory region 3353 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:8485393-8486592 Neighboring gene NANOG hESC enhancer GRCh37_chr9:8514616-8515117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:8600067-8600567 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:8643271-8644250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:8644251-8645230 Neighboring gene ribosomal protein L18a pseudogene 11 Neighboring gene RNA, U7 small nuclear 185 pseudogene Neighboring gene PTPRD antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1388 Neighboring gene ribosomal protein S26 pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:9556889-9557562 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:9577422-9577610 Neighboring gene RNA, 7SL, cytoplasmic 5, pseudogene Neighboring gene uncharacterized LOC105375972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:9914591-9915090 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:9998786-9999985 Neighboring gene NANOG hESC enhancer GRCh37_chr9:10011672-10012190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:10633883-10634384 Neighboring gene PTPRD divergent transcript Neighboring gene IMP3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Aberrant splicing of the PTPRD gene mimics microdeletions identified at this locus in neuroblastomas. Nair P, et al. Genes Chromosomes Cancer, 2008 Mar. PMID 18050303
    2. Protein tyrosine phosphatases receptor type D is a potential tumour suppressor gene inactivated by deoxyribonucleic acid methylation in paediatric acute myeloid leukaemia. Song L, et al. Acta Paediatr, 2016 Mar. PMID 26607758
    3. Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer. Sato M, et al. Genes Chromosomes Cancer, 2005 Dec. PMID 16114034
    4. Loss of Tyrosine Phosphatase Delta Promotes Gastric Cancer Progression via Signal Transducer and Activator of Transcription 3 Pathways. Wu L, et al. Dig Dis Sci, 2019 Nov. PMID 31041642
    5. Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. Painter JN, et al. Cancer Med, 2018 May. PMID 29608257, Free PMC Article

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein tyrosine phosphatase receptor type D gene promotes radiosensitivity via STAT3 dephosphorylation in nasopharyngeal carcinoma.
      Title: Protein tyrosine phosphatase receptor type D gene promotes radiosensitivity via STAT3 dephosphorylation in nasopharyngeal carcinoma.
    2. Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-delta to regulate adipogenesis.
      Title: Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-δ to regulate adipogenesis.
    3. PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas.
      Title: PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas.
    4. Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCgamma1 axis.
      Title: Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis.
    5. An integrative prognostic and immune analysis of PTPRD in cancer.
      Title: An integrative prognostic and immune analysis of PTPRD in cancer.
    6. Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development.
      Title: Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development.
    7. Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC.
      Title: Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC.
    8. IL1RAP regulated by PRPRD promotes gliomas progression via inducing neuronal synapse development and neuron differentiation in vitro.
      Title: IL1RAP regulated by PRPRD promotes gliomas progression via inducing neuronal synapse development and neuron differentiation in vitro.
    9. Altered PTPRD DNA methylation associates with restricted adipogenesis in healthy first-degree relatives of Type 2 diabetes subjects.
      Title: Altered PTPRD DNA methylation associates with restricted adipogenesis in healthy first-degree relatives of Type 2 diabetes subjects.
    10. DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.
      Title: DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.
    Submit: New GeneRIF Correction See all GeneRIFs (68)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
    EBI GWAS Catalog
    A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
    EBI GWAS Catalog
    A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
    EBI GWAS Catalog
    A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
    EBI GWAS Catalog
    Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
    EBI GWAS Catalog
    Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
    EBI GWAS Catalog
    Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog
    Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
    EBI GWAS Catalog
    Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
    EBI GWAS Catalog
    Genome-wide association study of co-occurring anxiety in major depression.
    EBI GWAS Catalog
    Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries.
    EBI GWAS Catalog
    Genome-wide association study of the five-factor model of personality in young Korean women.
    EBI GWAS Catalog
    Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119750, MGC119751, MGC119752, MGC119753

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine phosphatase signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to platelet-derived growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphate-containing compound metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in presynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic membrane assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic density assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in trans-synaptic signaling by trans-synaptic complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in trans-synaptic signaling by trans-synaptic complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase delta
    Names
    protein tyrosine phosphatase, receptor type, delta polypeptide
    rceptor-type tyrosine-protein phosphatase delta
    NP_001035802.1
    NP_001164496.1
    NP_001364875.1
    NP_001364876.1
    NP_001364887.1
    NP_001364987.1
    NP_002830.1
    NP_569075.2
    NP_569076.2
    NP_569077.2
    XP_006716880.1
    XP_006716886.1
    XP_006716888.1
    XP_006716890.1
    XP_016870447.1
    XP_016870450.1
    XP_016870452.1
    XP_016870453.1
    XP_016870454.1
    XP_016870455.1
    XP_016870456.1
    XP_016870457.1
    XP_016870458.1
    XP_016870459.1
    XP_016870460.1
    XP_016870461.1
    XP_016870463.1
    XP_016870465.1
    XP_016870466.1
    XP_016870467.1
    XP_016870468.1
    XP_016870469.1
    XP_016870471.1
    XP_016870472.1
    XP_024303393.1
    XP_047279597.1
    XP_047279598.1
    XP_047279599.1
    XP_047279600.1
    XP_047279601.1
    XP_047279602.1
    XP_047279603.1
    XP_047279604.1
    XP_047279605.1
    XP_047279606.1
    XP_047279607.1
    XP_047279608.1
    XP_047279609.1
    XP_047279610.1
    XP_047279611.1
    XP_047279612.1
    XP_047279613.1
    XP_047279614.1
    XP_047279615.1
    XP_047279616.1
    XP_054219364.1
    XP_054219365.1
    XP_054219366.1
    XP_054219367.1
    XP_054219368.1
    XP_054219369.1
    XP_054219370.1
    XP_054219371.1
    XP_054219372.1
    XP_054219373.1
    XP_054219374.1
    XP_054219375.1
    XP_054219376.1
    XP_054219377.1
    XP_054219378.1
    XP_054219379.1
    XP_054219380.1
    XP_054219381.1
    XP_054219382.1
    XP_054219383.1
    XP_054219384.1
    XP_054219385.1
    XP_054219386.1
    XP_054219387.1
    XP_054219388.1
    XP_054219389.1
    XP_054219390.1
    XP_054219391.1
    XP_054219392.1
    XP_054219393.1
    XP_054219394.1
    XP_054219395.1
    XP_054219396.1
    XP_054219397.1
    XP_054219398.1
    XP_054219399.1
    XP_054219400.1
    XP_054219401.1
    XP_054219402.1
    XP_054219403.1
    XP_054219404.1
    XP_054219405.1
    XP_054219406.1
    XP_054219407.1
    XP_054219408.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033963.1 RefSeqGene

      Range
      4722..2303478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040712.2 → NP_001035802.1  receptor-type tyrosine-protein phosphatase delta isoform 5 precursor

      See identical proteins and their annotated locations for NP_001035802.1

      Status: REVIEWED

      Source sequence(s)
      AB208869, AL356584, AL445926, AL590397, BM680342, DR001889
      Consensus CDS
      CCDS55288.1
      UniProtKB/TrEMBL
      F5GWR7
      Related
      ENSP00000380735.3, ENST00000397611.7
      Conserved Domains (8) summary
      cd05738
      Location:143 → 223
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:247 → 315
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:946 → 1201
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 222
      IG_like; Immunoglobulin like
      cd00047
      Location:972 → 1201
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:320 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    2. NM_001171025.2 → NP_001164496.1  receptor-type tyrosine-protein phosphatase delta isoform 6 precursor

      See identical proteins and their annotated locations for NP_001164496.1

      Status: REVIEWED

      Source sequence(s)
      AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
      Consensus CDS
      CCDS55289.1
      UniProtKB/TrEMBL
      F5GWR7
      Related
      ENSP00000380731.3, ENST00000397606.7
      Conserved Domains (8) summary
      cd05738
      Location:143 → 220
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:240 → 308
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:949 → 1204
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 219
      IG_like; Immunoglobulin like
      cd00047
      Location:975 → 1204
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:313 → 402
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    3. NM_001377946.1 → NP_001364875.1  receptor-type tyrosine-protein phosphatase delta isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
      UniProtKB/TrEMBL
      F5GWR7
      Conserved Domains (7) summary
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:931 → 1214
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1215 → 1506
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:32 → 36
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:127 → 220
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:233 → 314
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    4. NM_001377947.1 → NP_001364876.1  receptor-type tyrosine-protein phosphatase delta isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
      UniProtKB/TrEMBL
      F5GWR7
      Conserved Domains (7) summary
      cd00063
      Location:320 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:921 → 1204
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1205 → 1496
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:32 → 36
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:127 → 223
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:236 → 317
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    5. NM_001377958.1 → NP_001364887.1  receptor-type tyrosine-protein phosphatase delta isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (7) summary
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:1354 → 1637
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1638 → 1929
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:32 → 36
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:127 → 226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:239 → 320
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    6. NM_001378058.1 → NP_001364987.1  receptor-type tyrosine-protein phosphatase delta isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AL137125, AL356584, AL445926, AL583805, AL590397, AL596451
      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (7) summary
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:1339 → 1622
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1623 → 1914
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:32 → 36
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:127 → 226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:239 → 320
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    7. NM_002839.4 → NP_002830.1  receptor-type tyrosine-protein phosphatase delta isoform 1 precursor

      See identical proteins and their annotated locations for NP_002830.1

      Status: REVIEWED

      Source sequence(s)
      AB211400, AL135790, AL356584, AL390723, AL445926, BC028038, BM680342
      Consensus CDS
      CCDS43786.1
      UniProtKB/Swiss-Prot
      B1ALA0, F5GWT7, P23468, Q3KPJ0, Q3KPJ1, Q3KPJ2
      UniProtKB/TrEMBL
      Q2HXI4
      Related
      ENSP00000370593.3, ENST00000381196.9
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1356 → 1611
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1382 → 1611
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    8. NM_130391.4 → NP_569075.2  receptor-type tyrosine-protein phosphatase delta isoform 2 precursor

      See identical proteins and their annotated locations for NP_569075.2

      Status: REVIEWED

      Source sequence(s)
      AL137125, AL356584, AL445926, AL451130, AL583805, AL590397
      Consensus CDS
      CCDS6472.2
      UniProtKB/TrEMBL
      F5GWR7
      Related
      ENSP00000417093.1, ENST00000486161.5
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:949 → 1204
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:975 → 1204
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323 → 412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    9. NM_130392.3 → NP_569076.2  receptor-type tyrosine-protein phosphatase delta isoform 3 precursor

      See identical proteins and their annotated locations for NP_569076.2

      Status: REVIEWED

      Source sequence(s)
      AL445926, BC106714, BM680342, DR001889
      Consensus CDS
      CCDS55290.1
      UniProtKB/TrEMBL
      F5GWR7
      Related
      ENSP00000347373.5, ENST00000355233.9
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:950 → 1205
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:976 → 1205
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323 → 412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    10. NM_130393.3 → NP_569077.2  receptor-type tyrosine-protein phosphatase delta isoform 4 precursor

      See identical proteins and their annotated locations for NP_569077.2

      Status: REVIEWED

      Source sequence(s)
      AL445926, AL590397, BC106716, BM680342, DR001889
      Consensus CDS
      CCDS75813.1
      UniProtKB/TrEMBL
      F5GWR7, F5GWY7, Q3KPI9
      Related
      ENSP00000440515.2, ENST00000537002.5
      Conserved Domains (8) summary
      cd05738
      Location:143 → 220
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:244 → 312
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:940 → 1195
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 219
      IG_like; Immunoglobulin like
      cd00047
      Location:966 → 1195
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:317 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      8314246..10613002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014961.3 → XP_016870450.1  receptor-type tyrosine-protein phosphatase delta isoform X1

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (7) summary
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:1354 → 1637
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1638 → 1929
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:32 → 36
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:127 → 226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:239 → 320
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    2. XM_006716827.5 → XP_006716890.1  receptor-type tyrosine-protein phosphatase delta isoform X38

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (8) summary
      cd05738
      Location:143 → 217
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:237 → 305
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1337 → 1592
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 216
      IG_like; Immunoglobulin like
      cd00047
      Location:1363 → 1592
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:900 → 991
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    3. XM_047423649.1 → XP_047279605.1  receptor-type tyrosine-protein phosphatase delta isoform X28

    4. XM_047423651.1 → XP_047279607.1  receptor-type tyrosine-protein phosphatase delta isoform X30

    5. XM_047423657.1 → XP_047279613.1  receptor-type tyrosine-protein phosphatase delta isoform X37

    6. XM_047423653.1 → XP_047279609.1  receptor-type tyrosine-protein phosphatase delta isoform X33

    7. XM_017014971.3 → XP_016870460.1  receptor-type tyrosine-protein phosphatase delta isoform X13

      UniProtKB/TrEMBL
      Q2HXI4

    8. XM_024447625.2 → XP_024303393.1  receptor-type tyrosine-protein phosphatase delta isoform X12

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (6) summary
      cd05739
      Location:243 → 311
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1656 → 1915
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:1395 → 1624
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:915 → 1006
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cd05738
      Location:143 → 223
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    9. XM_017014966.3 → XP_016870455.1  receptor-type tyrosine-protein phosphatase delta isoform X6

      UniProtKB/TrEMBL
      Q2HXI4

    10. XM_017014969.3 → XP_016870458.1  receptor-type tyrosine-protein phosphatase delta isoform X11

      UniProtKB/TrEMBL
      Q2HXI4

    11. XM_047423645.1 → XP_047279601.1  receptor-type tyrosine-protein phosphatase delta isoform X23

    12. XM_017014967.3 → XP_016870456.1  receptor-type tyrosine-protein phosphatase delta isoform X7

      UniProtKB/TrEMBL
      Q2HXI4

    13. XM_017014983.3 → XP_016870472.1  receptor-type tyrosine-protein phosphatase delta isoform X43

      UniProtKB/TrEMBL
      F5GWR7

    14. XM_017014982.3 → XP_016870471.1  receptor-type tyrosine-protein phosphatase delta isoform X42

      UniProtKB/TrEMBL
      F5GWR7

    15. XM_047423654.1 → XP_047279610.1  receptor-type tyrosine-protein phosphatase delta isoform X34

    16. XM_017014980.3 → XP_016870469.1  receptor-type tyrosine-protein phosphatase delta isoform X31

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1347 → 1602
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1373 → 1602
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:913 → 1004
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    17. XM_047423644.1 → XP_047279600.1  receptor-type tyrosine-protein phosphatase delta isoform X19

    18. XM_017014974.3 → XP_016870463.1  receptor-type tyrosine-protein phosphatase delta isoform X15

      UniProtKB/TrEMBL
      Q2HXI4

    19. XM_047423652.1 → XP_047279608.1  receptor-type tyrosine-protein phosphatase delta isoform X32

    20. XM_047423650.1 → XP_047279606.1  receptor-type tyrosine-protein phosphatase delta isoform X29

    21. XM_017014977.3 → XP_016870466.1  receptor-type tyrosine-protein phosphatase delta isoform X17

      UniProtKB/TrEMBL
      Q2HXI4

    22. XM_017014972.3 → XP_016870461.1  receptor-type tyrosine-protein phosphatase delta isoform X14

      UniProtKB/TrEMBL
      Q2HXI4

    23. XM_047423647.1 → XP_047279603.1  receptor-type tyrosine-protein phosphatase delta isoform X26

    24. XM_006716817.5 → XP_006716880.1  receptor-type tyrosine-protein phosphatase delta isoform X5

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1373 → 1628
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1399 → 1628
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    25. XM_047423642.1 → XP_047279598.1  receptor-type tyrosine-protein phosphatase delta isoform X9

    26. XM_017014964.3 → XP_016870453.1  receptor-type tyrosine-protein phosphatase delta isoform X2

      UniProtKB/TrEMBL
      Q2HXI4

    27. XM_006716825.5 → XP_006716888.1  receptor-type tyrosine-protein phosphatase delta isoform X25

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1356 → 1611
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1382 → 1611
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    28. XM_017014970.3 → XP_016870459.1  receptor-type tyrosine-protein phosphatase delta isoform X10

      UniProtKB/TrEMBL
      Q2HXI4

    29. XM_017014979.3 → XP_016870468.1  receptor-type tyrosine-protein phosphatase delta isoform X21

      UniProtKB/TrEMBL
      Q2HXI4

    30. XM_017014965.3 → XP_016870454.1  receptor-type tyrosine-protein phosphatase delta isoform X4

      UniProtKB/TrEMBL
      Q2HXI4

    31. XM_006716823.4 → XP_006716886.1  receptor-type tyrosine-protein phosphatase delta isoform X22

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1357 → 1612
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1383 → 1612
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    32. XM_017014968.3 → XP_016870457.1  receptor-type tyrosine-protein phosphatase delta isoform X8

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1371 → 1626
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1397 → 1626
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    33. XM_017014978.3 → XP_016870467.1  receptor-type tyrosine-protein phosphatase delta isoform X20

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1361 → 1616
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1387 → 1616
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    34. XM_017014963.3 → XP_016870452.1  receptor-type tyrosine-protein phosphatase delta isoform X3

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (8) summary
      cd05738
      Location:143 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1375 → 1630
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:132 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1401 → 1630
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:41 → 115
      Ig; Immunoglobulin domain

    35. XM_017014976.3 → XP_016870465.1  receptor-type tyrosine-protein phosphatase delta isoform X18

      UniProtKB/TrEMBL
      Q2HXI4

    36. XM_017014958.3 → XP_016870447.1  receptor-type tyrosine-protein phosphatase delta isoform X1

      UniProtKB/TrEMBL
      Q2HXI4
      Conserved Domains (7) summary
      cd00063
      Location:922 → 1013
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14624
      Location:1354 → 1637
      R-PTPc-D-1; catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1
      cd14628
      Location:1638 → 1929
      R-PTP-D-2; PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2
      pfam07679
      Location:24 → 115
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:32 → 36
      Ig; Ig strand A' [structural motif]
      cd05738
      Location:127 → 226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:239 → 320
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    37. XM_047423641.1 → XP_047279597.1  receptor-type tyrosine-protein phosphatase delta isoform X1

    38. XM_047423660.1 → XP_047279616.1  receptor-type tyrosine-protein phosphatase delta isoform X41

    39. XM_047423659.1 → XP_047279615.1  receptor-type tyrosine-protein phosphatase delta isoform X40

    40. XM_047423648.1 → XP_047279604.1  receptor-type tyrosine-protein phosphatase delta isoform X27

    41. XM_047423658.1 → XP_047279614.1  receptor-type tyrosine-protein phosphatase delta isoform X39

    42. XM_047423646.1 → XP_047279602.1  receptor-type tyrosine-protein phosphatase delta isoform X24

      Related
      ENST00000651105.1

    43. XM_047423656.1 → XP_047279612.1  receptor-type tyrosine-protein phosphatase delta isoform X36

    44. XM_047423655.1 → XP_047279611.1  receptor-type tyrosine-protein phosphatase delta isoform X35

    45. XM_047423643.1 → XP_047279599.1  receptor-type tyrosine-protein phosphatase delta isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      8320802..10622316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363390.1 → XP_054219365.1  receptor-type tyrosine-protein phosphatase delta isoform X1

    2. XM_054363428.1 → XP_054219403.1  receptor-type tyrosine-protein phosphatase delta isoform X38

    3. XM_054363418.1 → XP_054219393.1  receptor-type tyrosine-protein phosphatase delta isoform X28

    4. XM_054363420.1 → XP_054219395.1  receptor-type tyrosine-protein phosphatase delta isoform X30

    5. XM_054363427.1 → XP_054219402.1  receptor-type tyrosine-protein phosphatase delta isoform X37

    6. XM_054363423.1 → XP_054219398.1  receptor-type tyrosine-protein phosphatase delta isoform X33

    7. XM_054363403.1 → XP_054219378.1  receptor-type tyrosine-protein phosphatase delta isoform X13

    8. XM_054363402.1 → XP_054219377.1  receptor-type tyrosine-protein phosphatase delta isoform X12

    9. XM_054363396.1 → XP_054219371.1  receptor-type tyrosine-protein phosphatase delta isoform X6

    10. XM_054363401.1 → XP_054219376.1  receptor-type tyrosine-protein phosphatase delta isoform X11

    11. XM_054363413.1 → XP_054219388.1  receptor-type tyrosine-protein phosphatase delta isoform X23

    12. XM_054363397.1 → XP_054219372.1  receptor-type tyrosine-protein phosphatase delta isoform X7

    13. XM_054363433.1 → XP_054219408.1  receptor-type tyrosine-protein phosphatase delta isoform X43

    14. XM_054363432.1 → XP_054219407.1  receptor-type tyrosine-protein phosphatase delta isoform X42

    15. XM_054363424.1 → XP_054219399.1  receptor-type tyrosine-protein phosphatase delta isoform X34

    16. XM_054363421.1 → XP_054219396.1  receptor-type tyrosine-protein phosphatase delta isoform X31

    17. XM_054363409.1 → XP_054219384.1  receptor-type tyrosine-protein phosphatase delta isoform X19

    18. XM_054363405.1 → XP_054219380.1  receptor-type tyrosine-protein phosphatase delta isoform X15

    19. XM_054363422.1 → XP_054219397.1  receptor-type tyrosine-protein phosphatase delta isoform X32

    20. XM_054363419.1 → XP_054219394.1  receptor-type tyrosine-protein phosphatase delta isoform X29

    21. XM_054363407.1 → XP_054219382.1  receptor-type tyrosine-protein phosphatase delta isoform X17

    22. XM_054363404.1 → XP_054219379.1  receptor-type tyrosine-protein phosphatase delta isoform X14

    23. XM_054363416.1 → XP_054219391.1  receptor-type tyrosine-protein phosphatase delta isoform X26

    24. XM_054363395.1 → XP_054219370.1  receptor-type tyrosine-protein phosphatase delta isoform X5

    25. XM_054363399.1 → XP_054219374.1  receptor-type tyrosine-protein phosphatase delta isoform X9

    26. XM_054363392.1 → XP_054219367.1  receptor-type tyrosine-protein phosphatase delta isoform X2

    27. XM_054363415.1 → XP_054219390.1  receptor-type tyrosine-protein phosphatase delta isoform X25

    28. XM_054363400.1 → XP_054219375.1  receptor-type tyrosine-protein phosphatase delta isoform X10

    29. XM_054363411.1 → XP_054219386.1  receptor-type tyrosine-protein phosphatase delta isoform X21

    30. XM_054363394.1 → XP_054219369.1  receptor-type tyrosine-protein phosphatase delta isoform X4

    31. XM_054363412.1 → XP_054219387.1  receptor-type tyrosine-protein phosphatase delta isoform X22

    32. XM_054363398.1 → XP_054219373.1  receptor-type tyrosine-protein phosphatase delta isoform X8

    33. XM_054363410.1 → XP_054219385.1  receptor-type tyrosine-protein phosphatase delta isoform X20

    34. XM_054363393.1 → XP_054219368.1  receptor-type tyrosine-protein phosphatase delta isoform X3

    35. XM_054363408.1 → XP_054219383.1  receptor-type tyrosine-protein phosphatase delta isoform X18

    36. XM_054363389.1 → XP_054219364.1  receptor-type tyrosine-protein phosphatase delta isoform X1

    37. XM_054363391.1 → XP_054219366.1  receptor-type tyrosine-protein phosphatase delta isoform X1

    38. XM_054363431.1 → XP_054219406.1  receptor-type tyrosine-protein phosphatase delta isoform X41

    39. XM_054363430.1 → XP_054219405.1  receptor-type tyrosine-protein phosphatase delta isoform X40

    40. XM_054363417.1 → XP_054219392.1  receptor-type tyrosine-protein phosphatase delta isoform X27

    41. XM_054363429.1 → XP_054219404.1  receptor-type tyrosine-protein phosphatase delta isoform X39

    42. XM_054363414.1 → XP_054219389.1  receptor-type tyrosine-protein phosphatase delta isoform X24

    43. XM_054363426.1 → XP_054219401.1  receptor-type tyrosine-protein phosphatase delta isoform X36

    44. XM_054363425.1 → XP_054219400.1  receptor-type tyrosine-protein phosphatase delta isoform X35

    45. XM_054363406.1 → XP_054219381.1  receptor-type tyrosine-protein phosphatase delta isoform X16

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23468.2 GenPept UniProtKB/Swiss-Prot:P23468

    Gene LinkOut

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