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    TDRG1 testis development related 1 [ Homo sapiens (human) ]

    Gene ID: 732253, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TDRG1provided by HGNC
    Official Full Name
    testis development related 1provided by HGNC
    Primary source
    HGNC:HGNC:43642
    See related
    Ensembl:ENSG00000204091 MIM:615676; AllianceGenome:HGNC:43642
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC00532; lincRNA-NR_024015
    Summary
    Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 38.5) See more
    Orthologs
    all
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    Genomic context

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    See TDRG1 in Genome Data Viewer
    Location:
    6p21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (40378337..40379893)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (40206234..40207790)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (40346076..40347632)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:40254197-40254754 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:40272571-40272754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:40275763-40276330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:40276331-40276897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:40289806-40290328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:40297426-40298064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:40298065-40298703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:40311845-40312560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:40313277-40313990 Neighboring gene long intergenic non-protein coding RNA 951 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:40327493-40328118 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:40346056-40347255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:40377247-40377748 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:40386520-40387156 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:40387157-40387792 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:40387793-40388428 Neighboring gene RNA, U6 small nuclear 250, pseudogene Neighboring gene leucine rich repeat and fibronectin type III domain containing 2 Neighboring gene uncharacterized LOC105379699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:40477543-40478043

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression and localization of testis developmental related gene 1 (TDRG1) in human spermatozoa. Chen H, et al. Tohoku J Exp Med, 2015 Feb. PMID 25749352
    2. TDRG1 functions in testicular seminoma are dependent on the PI3K/Akt/mTOR signaling pathway. Wang Y, et al. Onco Targets Ther, 2016. PMID 26855590, Free PMC Article
    3. TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway. Gan Y, et al. Cancer Biol Ther, 2016 Jul 2. PMID 27104982, Free PMC Article
    4. A genetic polymorphism at miR-526b binding-site in the lincRNA-NR_024015 exon confers risk of esophageal squamous cell carcinoma in a population of North China. Han L, et al. Mol Carcinog, 2017 Mar. PMID 27583835
    5. Novel insights into a treatment for aplastic anemia based on the advanced proliferation of bone marrow‑derived mesenchymal stem cells induced by fibroblast growth factor 1. Jiang S, et al. Mol Med Rep, 2015 Dec. PMID 26460236, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of Correlation Between LncRNA TDRG1 Expression and its Prognosis in Cervical Carcinoma Tissues.
      Title: Analysis of Correlation Between LncRNA TDRG1 Expression and its Prognosis in Cervical Carcinoma Tissues.
    2. Long non-coding RNA TDRG1 aggravates lung cancer stemness by binding to Sox2 mRNA.
      Title: Long non-coding RNA TDRG1 aggravates lung cancer stemness by binding to Sox2 mRNA.
    3. LncRNA TDRG1 promotes the metastasis of NSCLC cell through regulating miR-873-5p/ZEB1 axis.
      Title: LncRNA TDRG1 promotes the metastasis of NSCLC cell through regulating miR-873-5p/ZEB1 axis.
    4. The rs8506 TT Genotype in lincRNA-NR_024015 Contributes to the Risk of Sepsis in a Southern Chinese Child Population.
      Title: The rs8506 TT Genotype in lincRNA-NR_024015 Contributes to the Risk of Sepsis in a Southern Chinese Child Population.
    5. Long Noncoding RNAs Testis Development Related Gene 1 Aggravates Transforming Growth Factor-beta1-Induced Fibrogenesis and Inflammatory Response of Cardiac Fibroblasts Via miR-605-3p/Tumor Necrosis Factor Receptor Superfamily-21 Axis.
      Title: Long Noncoding RNAs Testis Development Related Gene 1 Aggravates Transforming Growth Factor-β1-Induced Fibrogenesis and Inflammatory Response of Cardiac Fibroblasts Via miR-605-3p/Tumor Necrosis Factor Receptor Superfamily-21 Axis.
    6. Long non-coding RNA TDRG1 facilitates cell proliferation, migration and invasion in breast cancer via targeting miR-214-5p/CLIC4 axis.
      Title: Long non-coding RNA TDRG1 facilitates cell proliferation, migration and invasion in breast cancer via targeting miR-214-5p/CLIC4 axis.
    7. Testis developmental related gene 1 (TDRG1) encodes a progressive motility-associated protein in human spermatozoa.
      Title: Testis developmental related gene 1 (TDRG1) encodes a progressive motility-associated protein in human spermatozoa.
    8. LncRNA TDRG1 promotes the proliferation, migration, and invasion of cervical cancer cells by sponging miR-214-5p to target SOX4.
      Title: LncRNA TDRG1 promotes the proliferation, migration, and invasion of cervical cancer cells by sponging miR-214-5p to target SOX4.
    9. LncRNA TDRG1/miR-214-5p axis affects preeclampsia by modulating trophoblast cells.
      Title: LncRNA TDRG1/miR-214-5p axis affects preeclampsia by modulating trophoblast cells.
    10. LncRNA TDRG1 functions as an oncogene in cervical cancer through sponging miR-330-5p to modulate ELK1 expression.
      Title: LncRNA TDRG1 functions as an oncogene in cervical cancer through sponging miR-330-5p to modulate ELK1 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Other Names

    • long intergenic non-protein coding RNA 532
    • testis development related 1 (non-protein coding)
    • testis development related gene 1
    • testis development related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_160958.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591063
      Related
      ENST00000373170.2

    2. NR_160959.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591063
      Related
      ENST00000653048.2

    3. NR_160960.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591063
      Related
      ENST00000448433.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      40378337..40379893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      40206234..40207790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001359094.1: Suppressed sequence

      Description
      NM_001359094.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    2. NM_001359095.1: Suppressed sequence

      Description
      NM_001359095.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

    3. NM_001359096.1: Suppressed sequence

      Description
      NM_001359096.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version

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