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    BOP1 BOP1 ribosomal biogenesis factor [ Homo sapiens (human) ]

    Gene ID: 23246, updated on 10-Dec-2024

    Summary

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    Official Symbol
    BOP1provided by HGNC
    Official Full Name
    BOP1 ribosomal biogenesis factorprovided by HGNC
    Primary source
    HGNC:HGNC:15519
    See related
    Ensembl:ENSG00000261236 MIM:610596; AllianceGenome:HGNC:15519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables RNA binding activity. Involved in regulation of cell cycle; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. Part of PeBoW complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 10.2), appendix (RPKM 9.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BOP1 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144262045..144291438, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145430815..145459890, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145316948..145331185, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19664 Neighboring gene testis specific serine kinase 5, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145220181-145220332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145220890-145221390 Neighboring gene maestro heat like repeat family member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145222845-145223346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145223347-145223846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145225713-145226214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145233092-145233905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145235445-145236162 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145236968-145237140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145239293-145239836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19665 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145321725-145322492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145322493-145323258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145494989-145495632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145495633-145496276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145498855-145499497 Neighboring gene microRNA 7112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19669 Neighboring gene scleraxis bHLH transcription factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19670 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19671 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145515765-145516421 Neighboring gene heat shock transcription factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145536471-145537002 Neighboring gene uncharacterized LOC124902050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28093 Neighboring gene microRNA 6848 Neighboring gene diacylglycerol O-acyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis. Killian A, et al. Genes Chromosomes Cancer, 2006 Sep. PMID 16804918
    2. Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression. Vellky JE, et al. Am J Pathol, 2021 Jan. PMID 33039351, Free PMC Article
    3. Block of proliferation 1 promotes cell migration and invasion in human colorectal cancer cells via the JNK pathway. Chen X, et al. J Clin Lab Anal, 2020 Jul. PMID 32167616, Free PMC Article
    4. BOP1 confers chemoresistance of triple-negative breast cancer by promoting CBP-mediated β-catenin acetylation. Li S, et al. J Pathol, 2021 Jul. PMID 33797754
    5. Block of proliferation 1 (BOP1) plays an oncogenic role in hepatocellular carcinoma by promoting epithelial-to-mesenchymal transition. Chung KY, et al. Hepatology, 2011 Jul. PMID 21520196

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDGF-C promotes cell proliferation partially via downregulating BOP1.
      Title: PDGF-C promotes cell proliferation partially via downregulating BOP1.
    2. BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway.
      Title: BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway.
    3. BOP1 confers chemoresistance of triple-negative breast cancer by promoting CBP-mediated beta-catenin acetylation.
      Title: BOP1 confers chemoresistance of triple-negative breast cancer by promoting CBP-mediated β-catenin acetylation.
    4. BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation.
      Title: BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation.
    5. BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis.
      Title: BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis.
    6. Block of proliferation 1 promotes cell migration and invasion in human colorectal cancer cells via the JNK pathway.
      Title: Block of proliferation 1 promotes cell migration and invasion in human colorectal cancer cells via the JNK pathway.
    7. The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling.
      Title: The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling.
    8. Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.
      Title: Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.
    9. Loss of which results in resistance to BRAF kinase inhibitors both in cell culture and in mice.
      Title: Loss of BOP1 confers resistance to BRAF kinase inhibitors in melanoma by activating MAP kinase pathway.
    10. The DDX27 can interact specifically with the Pes1 and Bop1 but fulfils critical function(s) for proper 3' end formation of 47S rRNA independently of the PeBoW-complex.
      Title: DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat downregulates the abundance of block of proliferation 1 (BOP1) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0124

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ribosome biogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PeBoW complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PeBoW complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosome biogenesis protein BOP1
    Names
    block of proliferation 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015201.5 → NP_056016.1  ribosome biogenesis protein BOP1

      See identical proteins and their annotated locations for NP_056016.1

      Status: VALIDATED

      Source sequence(s)
      AC145291, AI937005, BC013787, BQ711345, DA510177
      Consensus CDS
      CCDS6418.2
      UniProtKB/Swiss-Prot
      Q14137, Q969Z6, Q96IS8, Q96Q25, Q9BSA7, Q9BVM0
      UniProtKB/TrEMBL
      A8K3R2, B2RDN4
      Related
      ENSP00000455106.1, ENST00000569669.6
      Conserved Domains (4) summary
      COG2319
      Location:409 → 745
      WD40; WD40 repeat [General function prediction only]
      pfam08145
      Location:144 → 402
      BOP1NT; BOP1NT (NUC169) domain
      sd00039
      Location:417 → 453
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:408 → 745
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144262045..144291438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654716.1 Reference GRCh38.p14 PATCHES

      Range
      6826..22041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145430815..145459890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_027499.1: Suppressed sequence

      Description
      NG_027499.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14137.2 GenPept UniProtKB/Swiss-Prot:Q14137

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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