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    FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 26226, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FBXW4P1provided by HGNC
    Official Full Name
    F-box and WD repeat domain containing 4 pseudogene 1provided by HGNC
    Primary source
    HGNC:HGNC:13609
    See related
    Ensembl:ENSG00000230701 AllianceGenome:HGNC:13609
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBW3; FBXW3; SHFM3P1
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    Genomic context

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    See FBXW4P1 in Genome Data Viewer
    Location:
    22q11.23
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23262767..23265005)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (23685630..23687868)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (23604954..23607192)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene radial spoke head 14 homolog Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23521616-23522426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23526972-23527478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23534525-23535026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23535027-23535526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23536731-23537231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23541159-23542100 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23543528-23543704 Neighboring gene BCR pseudogene 8 Neighboring gene BCR activator of RhoGEF and GTPase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23559755-23560544 Neighboring gene BCR-ABL minor-breakpoint cluster region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18750 Neighboring gene Sharpr-MPRA regulatory region 5876 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23564024-23564225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:23571548-23572282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18751 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23584482-23585232 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23585233-23585984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23591289-23591814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23599428-23600084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18753 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:23611303-23611973 Neighboring gene BCR-ABL p195 breakpoint cluster region Neighboring gene RNA, 7SL, cytoplasmic 263, pseudogene Neighboring gene BCR-ABL p200 breakpoint cluster region Neighboring gene ReSE screen-validated silencer GRCh37_chr22:23621943-23622250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13538 Neighboring gene uncharacterized LOC107985554 Neighboring gene BCR-ABL major-breakpoint cluster region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18755 Neighboring gene BCR-ABL p225 breakpoint cluster region Neighboring gene BCR-ABL micro-breakpoint cluster region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:23656171-23656672 Neighboring gene Sharpr-MPRA regulatory region 15419 Neighboring gene POM121 transmembrane nucleoporin like 11, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel human gene encoding an F-box/WD40 containing protein maps in the SHFM3 critical region on 10q24. Ianakiev P, et al. Biochem Biophys Res Commun, 1999 Jul 22. PMID 10405324
    2. Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. Chissoe SL, et al. Genomics, 1995 May 1. PMID 7665185
    3. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Groffen J, et al. Cell, 1984 Jan. PMID 6319012
    4. Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Patton EE, et al. Trends Genet, 1998 Jun. PMID 9635407
    5. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Watanabe N, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070733, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • F-box and WD-40 domain protein 3
    • split hand/foot malformation (ectrodactyly) type 3 pseudogene 1

    Clone Names

    • FLJ94893

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_033408.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF174606, AI432341, BP385887, BX091573, U07000
      Related
      ENST00000426721.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      23262767..23265005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      23685630..23687868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_005085.3: Suppressed sequence

      Description
      NG_005085.3: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.

    2. NG_027469.1: Suppressed sequence

      Description
      NG_027469.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.

    3. NM_012165.1: Suppressed sequence

      Description
      NM_012165.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version

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