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    ZNF697 zinc finger protein 697 [ Homo sapiens (human) ]

    Gene ID: 90874, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF697provided by HGNC
    Official Full Name
    zinc finger protein 697provided by HGNC
    Primary source
    HGNC:HGNC:32034
    See related
    Ensembl:ENSG00000143067 MIM:620981; AllianceGenome:HGNC:32034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFP697
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 3.1), placenta (RPKM 2.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF697 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (119619377..119648266, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (119632580..119661937, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120162000..120190889, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 622 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:120147336-120148535 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 5 Neighboring gene MPRA-validated peak396 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1246 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:120190306-120190469 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1247 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:120190885-120191725 Neighboring gene uncharacterized LOC124904389 Neighboring gene Sharpr-MPRA regulatory region 8207 Neighboring gene uncharacterized LOC124904390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1595

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    2. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
    3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
    4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053
    5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45731

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 697

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080470.2 → NP_001073939.1  zinc finger protein 697

      See identical proteins and their annotated locations for NP_001073939.1

      Status: VALIDATED

      Source sequence(s)
      AL109966
      Consensus CDS
      CCDS44202.1
      UniProtKB/Swiss-Prot
      Q5TEC3, Q96IT2
      Related
      ENSP00000396857.2, ENST00000421812.3
      Conserved Domains (3) summary
      COG5048
      Location:364 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:439 → 459
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:480 → 504
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      119619377..119648266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271315.4 → XP_005271372.1  zinc finger protein 697 isoform X1

      See identical proteins and their annotated locations for XP_005271372.1

      UniProtKB/Swiss-Prot
      Q5TEC3, Q96IT2
      Conserved Domains (3) summary
      COG5048
      Location:364 → 545
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:439 → 459
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:480 → 504
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047433849.1 → XP_047289805.1  zinc finger protein 697 isoform X1

      UniProtKB/Swiss-Prot
      Q5TEC3, Q96IT2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      119632580..119661937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339533.1 → XP_054195508.1  zinc finger protein 697 isoform X1

      UniProtKB/Swiss-Prot
      Q5TEC3, Q96IT2

    2. XM_054339534.1 → XP_054195509.1  zinc finger protein 697 isoform X1

      UniProtKB/Swiss-Prot
      Q5TEC3, Q96IT2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138366.1: Suppressed sequence

      Description
      NM_138366.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TEC3.2 GenPept UniProtKB/Swiss-Prot:Q5TEC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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