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    TCF3 transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 6929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TCF3provided by HGNC
    Official Full Name
    transcription factor 3provided by HGNC
    Primary source
    HGNC:HGNC:11633
    See related
    Ensembl:ENSG00000071564 MIM:147141; AllianceGenome:HGNC:11633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E2A; E47; p75; AGM8; ITF1; VDIR; AGM8A; AGM8B; TCF-3; bHLHb21
    Summary
    This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
    Expression
    Broad expression in testis (RPKM 16.2), lymph node (RPKM 12.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TCF3 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1609292..1652615, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1580117..1623781, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1609291..1652614, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584307-1584918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584919-1585529 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1590888-1591877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13615 Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1606417-1607038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13618 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit XI Neighboring gene RNA, U6 small nuclear 1223, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1626353-1626854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1649155-1649654 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1651633-1651855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9740 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13623 Neighboring gene MPRA-validated peak3223 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1667070-1667570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1668943-1669693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1672373-1672900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1690448-1690998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1690999-1691550 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1722988-1723177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1725449-1725948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1743285-1743784 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1743951-1744173 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:1747113-1748312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1748390-1748908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1757201-1757790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1757791-1758378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1762447-1762983 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1765801-1766322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1767617-1768311 Neighboring gene one cut homeobox 3 Neighboring gene uncharacterized LOC101928543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1789295-1790117 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1795609-1796421 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1796422-1797233 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1799861-1800031 Neighboring gene ATPase phospholipid transporting 8B3 Neighboring gene MPRA-validated peak3225 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1811783-1812528

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors. Zhang X, et al. Leukemia, 2012 Dec. PMID 22743623
    2. Genomic loss of the putative tumor suppressor gene E2A in human lymphoma. Steininger A, et al. J Exp Med, 2011 Aug 1. PMID 21788410, Free PMC Article
    3. Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. Schwartz R, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16782810, Free PMC Article
    4. Overexpression of transcription factor 3 drives hepatocarcinoma development by enhancing cell proliferation via activating Wnt signaling pathway. Pu XY, et al. Hepatobiliary Pancreat Dis Int, 2022 Aug. PMID 35033448
    5. Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors. Mehmood R, et al. Mol Biol Cell, 2011 Oct. PMID 21832153, Free PMC Article

    See all (294) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Embryonic stem cell related gene regulates alternative splicing of transcription factor 3 to maintain human embryonic stem cells' self-renewal and pluripotency.
      Title: Embryonic stem cell related gene regulates alternative splicing of transcription factor 3 to maintain human embryonic stem cells' self-renewal and pluripotency.
    2. Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis.
      Title: Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis.
    3. Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia.
      Title: Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia.
    4. Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.
      Title: Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.
    5. E47 as a novel glucocorticoid-dependent gene mediating lipid metabolism in patients with endogenous glucocorticoid excess.
      Title: E47 as a novel glucocorticoid-dependent gene mediating lipid metabolism in patients with endogenous glucocorticoid excess.
    6. TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.
      Title: TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.
    7. Molecular characterization of TCF3::PBX1 chromosomal breakpoints in acute lymphoblastic leukemia and their use for measurable residual disease assessment.
      Title: Molecular characterization of TCF3::PBX1 chromosomal breakpoints in acute lymphoblastic leukemia and their use for measurable residual disease assessment.
    8. Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma.
      Title: Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma.
    9. Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
      Title: Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
    10. Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia.
      Title: Identification of TCF3 germline variants in pediatric B-cell acute lymphoblastic leukemia.
    Submit: New GeneRIF Correction See all GeneRIFs (136)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Agammaglobulinemia 8, autosomal dominant
    MedGen: C4310786 OMIM: 616941 GeneReviews: Not available
    		Compare labs
    Agammaglobulinemia 8b, autosomal recessive
    MedGen: C5676958 OMIM: 619824 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129647, MGC129648

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to E-box binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to E-box binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to E-box binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables bHLH transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables vitamin D response element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in B cell lineage commitment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in B cell lineage commitment NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in immunoglobulin V(D)J recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within immunoglobulin V(D)J recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor E2-alpha
    Names
    E2A-HLF fusion transcript protein
    NOL1-TCF3 fusion
    VDR interacting repressor
    class B basic helix-loop-helix protein 21
    helix-loop-helix protein HE47
    immunoglobulin transcription factor 1
    kappa-E2-binding factor
    negative vitamin D response element-binding protein
    transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
    transcription factor ITF-1
    vitamin D receptor-interacting repressor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029953.2 RefSeqGene

      Range
      4932..48255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1325

    mRNA and Protein(s)

    1. NM_001136139.4 → NP_001129611.1  transcription factor E2-alpha isoform E47

      See identical proteins and their annotated locations for NP_001129611.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, lacks an exon and includes an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (E47, also known as Pan-1) is shorter than isoform E12. Variants 2 and 4 encode the same isoform (E47).
      Source sequence(s)
      AC005321, AC006274, AW028755, BG284440, BU528547, CD516687, CD674814, KC877695, M24404
      Consensus CDS
      CCDS45899.1
      UniProtKB/TrEMBL
      X6REB3
      Related
      ENSP00000468487.1, ENST00000588136.7
      Conserved Domains (1) summary
      cd18943
      Location:538 → 611
      bHLH_E-protein_E47-like; basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins

    2. NM_001351778.2 → NP_001338707.1  transcription factor E2-alpha isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, and contains an alternate splice structure in the 3' region, resulting in differences in the 3' UTR. The encoded isoform (3) has the same N- and C-termini, but is one aa shorter than isoform 1.
      Source sequence(s)
      AA251176, AC006274, AW968445, KC877695, M31222
      UniProtKB/TrEMBL
      Q6PJU3
      Conserved Domains (2) summary
      smart00353
      Location:554 → 607
      HLH; helix loop helix domain
      pfam03985
      Location:495 → 549
      Paf1; Paf1

    3. NM_001351779.2 → NP_001338708.1  transcription factor E2-alpha isoform E47

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate penultimate exon compared to variant 1. The encoded isoform (E47, also known as Pan-1) is shorter than isoform E12. Variants 2 and 4 encode the same isoform (E47).
      Source sequence(s)
      AC005321, AC006274, AW028755, BG284440, KC877695, M24404, M31222
      Consensus CDS
      CCDS45899.1
      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      cd18943
      Location:538 → 611
      bHLH_E-protein_E47-like; basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins

    4. NM_003200.5 → NP_003191.1  transcription factor E2-alpha isoform E12

      See identical proteins and their annotated locations for NP_003191.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (E12). This isoform is also known as Pan-2.
      Source sequence(s)
      AC005321, AC006274, KC877695, M31222
      Consensus CDS
      CCDS12074.1
      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
      Related
      ENSP00000262965.5, ENST00000262965.12
      Conserved Domains (2) summary
      smart00353
      Location:555 → 608
      HLH; helix loop helix domain
      pfam03985
      Location:496 → 549
      Paf1; Paf1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      1609292..1652615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439298.1 → XP_047295254.1  transcription factor E2-alpha isoform X12

      UniProtKB/TrEMBL
      U5LXR9

    2. XM_047439297.1 → XP_047295253.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9

    3. XM_047439296.1 → XP_047295252.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9
      Related
      ENSP00000378813.3, ENST00000395423.7

    4. XM_047439294.1 → XP_047295250.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9

    5. XM_047439290.1 → XP_047295246.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3

    6. XM_047439286.1 → XP_047295242.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3

    7. XM_011528226.3 → XP_011526528.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      smart00353
      Location:551 → 604
      HLH; helix loop helix domain

    8. XM_047439279.1 → XP_047295235.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3

    9. XM_047439285.1 → XP_047295241.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    10. XM_011528225.3 → XP_011526527.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      smart00353
      Location:551 → 604
      HLH; helix loop helix domain

    11. XM_047439284.1 → XP_047295240.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    12. XM_047439283.1 → XP_047295239.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    13. XM_047439278.1 → XP_047295234.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    14. XM_047439277.1 → XP_047295233.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    15. XM_017027181.2 → XP_016882670.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3
      Conserved Domains (2) summary
      smart00353
      Location:555 → 608
      HLH; helix loop helix domain
      pfam03985
      Location:496 → 549
      Paf1; Paf1

    16. XM_047439261.1 → XP_047295217.1  transcription factor E2-alpha isoform X2

      UniProtKB/TrEMBL
      X6REB3

    17. XM_017027178.2 → XP_016882667.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      smart00353
      Location:581 → 634
      HLH; helix loop helix domain

    18. XM_047439262.1 → XP_047295218.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3
      Related
      ENSP00000396363.3, ENST00000453954.6

    19. XM_006722855.5 → XP_006722918.1  transcription factor E2-alpha isoform X3

      See identical proteins and their annotated locations for XP_006722918.1

      UniProtKB/TrEMBL
      X6REB3
      Conserved Domains (1) summary
      smart00353
      Location:581 → 634
      HLH; helix loop helix domain

    20. XM_047439259.1 → XP_047295215.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3

    21. XM_047439260.1 → XP_047295216.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3

    22. XM_047439295.1 → XP_047295251.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9

    23. XM_047439291.1 → XP_047295247.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3

    24. XM_047439280.1 → XP_047295236.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3

    25. XM_047439289.1 → XP_047295245.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    26. XM_047439287.1 → XP_047295243.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    27. XM_047439282.1 → XP_047295238.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    28. XM_047439281.1 → XP_047295237.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    29. XM_047439276.1 → XP_047295232.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    30. XM_047439258.1 → XP_047295214.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3

    31. XM_047439293.1 → XP_047295249.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9

    32. XM_047439292.1 → XP_047295248.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9

    33. XM_047439275.1 → XP_047295231.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3

    34. XM_047439274.1 → XP_047295230.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3

    35. XM_047439273.1 → XP_047295229.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3

    36. XM_047439271.1 → XP_047295227.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3

    37. XM_047439267.1 → XP_047295223.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3

    38. XM_047439266.1 → XP_047295222.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3

    39. XM_047439288.1 → XP_047295244.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    40. XM_047439272.1 → XP_047295228.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    41. XM_047439270.1 → XP_047295226.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    42. XM_047439269.1 → XP_047295225.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    43. XM_047439268.1 → XP_047295224.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    44. XM_047439265.1 → XP_047295221.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    45. XM_047439264.1 → XP_047295220.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    46. XM_047439263.1 → XP_047295219.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      1580117..1623781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321896.1 → XP_054177871.1  transcription factor E2-alpha isoform X12

      UniProtKB/TrEMBL
      U5LXR9

    2. XM_054321895.1 → XP_054177870.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9

    3. XM_054321894.1 → XP_054177869.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9

    4. XM_054321892.1 → XP_054177867.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9

    5. XM_054321888.1 → XP_054177863.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3

    6. XM_054321883.1 → XP_054177858.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3

    7. XM_054321880.1 → XP_054177855.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3

    8. XM_054321869.1 → XP_054177844.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3

    9. XM_054321882.1 → XP_054177857.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    10. XM_054321878.1 → XP_054177853.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    11. XM_054321877.1 → XP_054177852.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    12. XM_054321875.1 → XP_054177850.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    13. XM_054321868.1 → XP_054177843.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    14. XM_054321866.1 → XP_054177841.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    15. XM_054321864.1 → XP_054177839.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    16. XM_054321854.1 → XP_054177829.1  transcription factor E2-alpha isoform X2

      UniProtKB/TrEMBL
      X6REB3

    17. XM_054321856.1 → XP_054177831.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3

    18. XM_054321857.1 → XP_054177832.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3

    19. XM_054321855.1 → XP_054177830.1  transcription factor E2-alpha isoform X3

      UniProtKB/TrEMBL
      X6REB3

    20. XM_054321852.1 → XP_054177827.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3

    21. XM_054321853.1 → XP_054177828.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3

    22. XM_054321893.1 → XP_054177868.1  transcription factor E2-alpha isoform X11

      UniProtKB/TrEMBL
      U5LXR9

    23. XM_054321889.1 → XP_054177864.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3

    24. XM_054321871.1 → XP_054177846.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3

    25. XM_054321887.1 → XP_054177862.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    26. XM_054321885.1 → XP_054177860.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    27. XM_054321873.1 → XP_054177848.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    28. XM_054321872.1 → XP_054177847.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    29. XM_054321862.1 → XP_054177837.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    30. XM_054321851.1 → XP_054177826.1  transcription factor E2-alpha isoform X1

      UniProtKB/TrEMBL
      X6REB3

    31. XM_054321886.1 → XP_054177861.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    32. XM_054321858.1 → XP_054177833.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3

    33. XM_054321870.1 → XP_054177845.1  transcription factor E2-alpha isoform X5

      UniProtKB/TrEMBL
      Q6PJU3

    34. XM_054321867.1 → XP_054177842.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    35. XM_054321865.1 → XP_054177840.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    36. XM_054321860.1 → XP_054177835.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3

    37. XM_054321884.1 → XP_054177859.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3

    38. XM_054321881.1 → XP_054177856.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    39. XM_054321861.1 → XP_054177836.1  transcription factor E2-alpha isoform X9

      UniProtKB/TrEMBL
      X6REB3

    40. XM_054321859.1 → XP_054177834.1  transcription factor E2-alpha isoform X8

      UniProtKB/TrEMBL
      X6REB3

    41. XM_054321879.1 → XP_054177854.1  transcription factor E2-alpha isoform X7

      UniProtKB/TrEMBL
      X6REB3

    42. XM_054321876.1 → XP_054177851.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    43. XM_054321874.1 → XP_054177849.1  transcription factor E2-alpha isoform X6

      UniProtKB/TrEMBL
      X6REB3

    44. XM_054321863.1 → XP_054177838.1  transcription factor E2-alpha isoform X4

      UniProtKB/Swiss-Prot
      P15883, P15923, Q14208, Q14635, Q14636, Q2TB39, Q2TB40, Q9UPI9
      UniProtKB/TrEMBL
      Q6PJU3

    45. XM_054321891.1 → XP_054177866.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9

    46. XM_054321890.1 → XP_054177865.1  transcription factor E2-alpha isoform X10

      UniProtKB/TrEMBL
      U5LXR9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15923.1 GenPept UniProtKB/Swiss-Prot:P15923

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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