DLC1 DLC1 Rho GTPase activating protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: DLC1provided by HGNC
Official Full Name: DLC1 Rho GTPase activating proteinprovided by HGNC
Primary source: HGNC:HGNC:2897
See related: Ensembl:ENSG00000164741 MIM:604258; AllianceGenome:HGNC:2897
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HP; ARHGAP7; STARD12; p122-RhoGAP
Summary: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
Annotation information: Note: DLC1 (Gene ID: 10395) and DYNLL1 (Gene ID: 8655) share the DLC1 symbol/alias in common. DLC1 is sometimes used as an alternative name for dynein light chain LC8-type 1 (DYNLL1), which can be confused with the official symbol for DLC1 Rho GTPase activating protein (DLC1). [05 Jul 2018]
Expression: Broad expression in lung (RPKM 21.4), fat (RPKM 12.0) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p22

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (13083361..13604620, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (13349832..13871204, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (12940870..13462129, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DLC1 promotes mechanotransductive feedback for YAP via RhoGAP-mediated focal adhesion turnover.
Title: DLC1 promotes mechanotransductive feedback for YAP via RhoGAP-mediated focal adhesion turnover.
Aberrant DNA Methylation Patterns of Deleted in Liver Cancer 1 Isoforms in Hepatocellular Carcinoma.
Title: Aberrant DNA Methylation Patterns of Deleted in Liver Cancer 1 Isoforms in Hepatocellular Carcinoma.
NBR2/miR-561-5p/DLC1 axis inhibited the development of multiple myeloma by activating the AMPK/mTOR pathway to repress glycolysis.
Title: NBR2/miR-561-5p/DLC1 axis inhibited the development of multiple myeloma by activating the AMPK/mTOR pathway to repress glycolysis.
Frequent Downregulation and Promoter Hypermethylation of DLC1: Relationship with Clinical Outcome in Gallbladder Cancer.
Title: Frequent Downregulation and Promoter Hypermethylation of DLC1: Relationship with Clinical Outcome in Gallbladder Cancer.
MiR-200a-3p promotes gastric cancer progression by targeting DLC-1.
Title: MiR-200a-3p promotes gastric cancer progression by targeting DLC-1.
The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1.
Title: The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1.
Association of deleted in liver cancer-1 gene polymorphism with increased risk of chronicity of disease among Malaysian patients with hepatitis B infection.
Title: Association of deleted in liver cancer-1 gene polymorphism with increased risk of chronicity of disease among Malaysian patients with hepatitis B infection.
DLC1 inhibits lung adenocarcinoma cell proliferation, migration and invasion via regulating MAPK signaling pathway.
Title: DLC1 inhibits lung adenocarcinoma cell proliferation, migration and invasion via regulating MAPK signaling pathway.
CircZKSCAN1 Suppresses Hepatocellular Carcinoma Tumorigenesis by Regulating miR-873-5p/Downregulation of Deleted in Liver Cancer 1.
Title: CircZKSCAN1 Suppresses Hepatocellular Carcinoma Tumorigenesis by Regulating miR-873-5p/Downregulation of Deleted in Liver Cancer 1.
MIR-301b-3p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting DLC1.
Title: MIR-301b-3p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting DLC1.

Submit: New GeneRIF Correction See all GeneRIFs (148)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	Compare labs

EBI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12354 (e-PCR)
- UniSTS:78592

D8S1754 (e-PCR), detects polymorphism
- UniSTS:26626

RH103734 (e-PCR)
- UniSTS:98059

D8S1790 (e-PCR), detects polymorphism
- UniSTS:70178

RH12088 (e-PCR)
- UniSTS:80675

STS-N74419 (e-PCR)
- UniSTS:69668

D8S1636 (e-PCR)
- UniSTS:22311

D9Mco7 (e-PCR)
- UniSTS:239669

D8S13124 (e-PCR)
- UniSTS:265018

D8S13129 (e-PCR)
- UniSTS:265019

D8S13141 (e-PCR)
- UniSTS:265020

RH123765 (e-PCR)
- UniSTS:137789

SHGC-31942 (e-PCR)
- UniSTS:15689

SHGC-142756 (e-PCR)
- UniSTS:171636

D8S1690 (e-PCR)
- UniSTS:154267

G19789 (e-PCR)
- UniSTS:32670

A001Y28 (e-PCR)
- UniSTS:32671

D8S1182 (e-PCR)
- UniSTS:150192

RH69819 (e-PCR)
- UniSTS:50358

G59317 (e-PCR)
- UniSTS:136632

SHGC-80952 (e-PCR)
- UniSTS:102585

WI-18560 (e-PCR)
- UniSTS:16060

G63522 (e-PCR)
- UniSTS:140484

WIAF-1709 (e-PCR)
- UniSTS:24782

G10585 (e-PCR)
- UniSTS:51409

SHGC-83879 (e-PCR)
- UniSTS:101847

WI-22147 (e-PCR)
- UniSTS:25569

D8S1513 (e-PCR)
- UniSTS:47075

SHGC-57503 (e-PCR)
- UniSTS:19950

SHGC-57963 (e-PCR)
- UniSTS:73459

PMC97615P1 (e-PCR)
- UniSTS:273655

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activator activity	TAS Traceable Author Statement more info
enables SH2 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in forebrain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hindbrain morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in neural tube closure	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rho GTPase-activating protein 7

Names: Rho-GTPase-activating protein 7; START domain-containing protein 12; StAR-related lipid transfer (START) domain containing 12; deleted in liver cancer 1 protein; epididymis secretory sperm binding protein; rho-type GTPase-activating protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015998.2 RefSeqGene

Range

94755..526245

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001164271.2 → NP_001157743.1 rho GTPase-activating protein 7 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1. Variants 4, 7, 8, and 9 all encode the same isoform (4).

Source sequence(s)

AC015641, AF026219, AK289734, AK299049

Consensus CDS

CCDS55201.1

UniProtKB/TrEMBL

A0AAG2U1V2

Related

ENSP00000428028.1, ENST00000520226.5

Conserved Domains (2) summary

cd08908
Location:804 → 1007

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd04375
Location:561 → 779

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
NM_001316668.2 → NP_001303597.1 rho GTPase-activating protein 7 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate exon in place of the first 5 exons compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AB051510, AC015641, DA401187

Consensus CDS

CCDS83253.1

UniProtKB/TrEMBL

A0AAG2U1V2

Related

ENSP00000422595.2, ENST00000512044.6

Conserved Domains (3) summary

cd08908
Location:912 → 1115

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:51 → 110

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:669 → 887

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
NM_001348081.2 → NP_001335010.1 rho GTPase-activating protein 7 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variant 1, encodes isoform 1.

Source sequence(s)

AC015641, AC019270, AC022832, AC022844, AC106845

Consensus CDS

CCDS5989.1

UniProtKB/Swiss-Prot

B4DR10, B8PTI0, E9PDZ8, E9PF76, E9PGY9, O14868, O43199, Q7Z5R8, Q86UC6, Q96QB1, Q9C0E0, Q9H7A2

UniProtKB/TrEMBL

A8K6L7

Conserved Domains (3) summary

cd08908
Location:1315 → 1518

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:454 → 513

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1072 → 1290

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
NM_001348082.2 → NP_001335011.1 rho GTPase-activating protein 7 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 4, 8, and 9, encodes isoform 4.

Source sequence(s)

AC015641, AC019270, AC022832, AC022844, AC106845

Consensus CDS

CCDS55201.1

UniProtKB/TrEMBL

A0AAG2U1V2

Conserved Domains (2) summary

cd08908
Location:804 → 1007

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd04375
Location:561 → 779

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
NM_001348083.1 → NP_001335012.1 rho GTPase-activating protein 7 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (8), as well as variants 4, 7, and 9, encodes isoform 4.

Source sequence(s)

AC015641, AC106845

Consensus CDS

CCDS55201.1

UniProtKB/TrEMBL

A0AAG2U1V2

Conserved Domains (2) summary

cd08908
Location:804 → 1007

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd04375
Location:561 → 779

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
NM_001348084.2 → NP_001335013.1 rho GTPase-activating protein 7 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (9), as well as variants 4, 7, and 8, encodes isoform 4.

Source sequence(s)

AC015641

Consensus CDS

CCDS55201.1

UniProtKB/TrEMBL

A0AAG2U1V2

Conserved Domains (2) summary

cd08908
Location:804 → 1007

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd04375
Location:561 → 779

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
NM_001413124.1 → NP_001400053.1 rho GTPase-activating protein 7 isoform 1

Status: REVIEWED

Source sequence(s)

AC015641, AC019270, AC022844, AC106845

UniProtKB/Swiss-Prot

B4DR10, B8PTI0, E9PDZ8, E9PF76, E9PGY9, O14868, O43199, Q7Z5R8, Q86UC6, Q96QB1, Q9C0E0, Q9H7A2
NM_001413125.1 → NP_001400054.1 rho GTPase-activating protein 7 isoform 14

Status: REVIEWED

Source sequence(s)

AC019270, AC022844, AC106845
NM_001413126.1 → NP_001400055.1 rho GTPase-activating protein 7 isoform 4

Status: REVIEWED

Source sequence(s)

AC015641, AC106845
NM_001413127.1 → NP_001400056.1 rho GTPase-activating protein 7 isoform 4

Status: REVIEWED

Source sequence(s)

AC015641, AC106845
NM_001413128.1 → NP_001400057.1 rho GTPase-activating protein 7 isoform 4

Status: REVIEWED

Source sequence(s)

AC015641, AC106845
NM_001413129.1 → NP_001400058.1 rho GTPase-activating protein 7 isoform 6

Status: REVIEWED

Source sequence(s)

AC015641, AC106845
NM_001413130.1 → NP_001400059.1 rho GTPase-activating protein 7 isoform 7

Status: REVIEWED

Source sequence(s)

AC015641, AC106845
NM_001413131.1 → NP_001400060.1 rho GTPase-activating protein 7 isoform 8

Status: REVIEWED

Source sequence(s)

AC015641, AC106845
NM_001413132.1 → NP_001400061.1 rho GTPase-activating protein 7 isoform 9

Status: REVIEWED

Source sequence(s)

AC015641, AC106845
NM_001413133.1 → NP_001400062.1 rho GTPase-activating protein 7 isoform 4

Status: REVIEWED

Source sequence(s)

AC015641, AC106845
NM_001413134.1 → NP_001400063.1 rho GTPase-activating protein 7 isoform 10

Status: REVIEWED

Source sequence(s)

AC106845
NM_001413135.1 → NP_001400064.1 rho GTPase-activating protein 7 isoform 11

Status: REVIEWED

Source sequence(s)

AC015641
NM_001413136.1 → NP_001400065.1 rho GTPase-activating protein 7 isoform 12

Status: REVIEWED

Source sequence(s)

AC015641
NM_001413137.1 → NP_001400066.1 rho GTPase-activating protein 7 isoform 8

Status: REVIEWED

Source sequence(s)

AC015641
NM_001413138.1 → NP_001400067.1 rho GTPase-activating protein 7 isoform 4

Status: REVIEWED

Source sequence(s)

AC015641
NM_001413139.1 → NP_001400068.1 rho GTPase-activating protein 7 isoform 15

Status: REVIEWED

Source sequence(s)

AC015641
NM_001413140.1 → NP_001400069.1 rho GTPase-activating protein 7 isoform 16

Status: REVIEWED

Source sequence(s)

AC015641
NM_006094.5 → NP_006085.2 rho GTPase-activating protein 7 isoform 2

See identical proteins and their annotated locations for NP_006085.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks a portion of the 5' coding region, and represents use of an alternate promoter, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variant 2 represents the predominant transcript.

Source sequence(s)

AC015641, BC095415

Consensus CDS

CCDS5990.1

UniProtKB/TrEMBL

A0AAG2UXB5, A8K119

Related

ENSP00000351797.2, ENST00000358919.6

Conserved Domains (4) summary

cd08908
Location:878 → 1081

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:17 → 76

SAM_DLC1; SAM domain of DLC1 subfamily

smart00454
Location:17 → 76

SAM; Sterile alpha motif

cd04375
Location:635 → 853

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
NM_024767.5 → NP_079043.3 rho GTPase-activating protein 7 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC022844, AC106845, BC049842, DA549448

Consensus CDS

CCDS5991.2

UniProtKB/Swiss-Prot

Q96QB1

Related

ENSP00000425878.1, ENST00000511869.1
NM_182643.3 → NP_872584.2 rho GTPase-activating protein 7 isoform 1

See identical proteins and their annotated locations for NP_872584.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variant 1 represents a transcript that is found in low abundance. Variants 1 and 6 both encode the same isoform (1).

Source sequence(s)

AB051510, AC015641, AC022844, BC054511, DA549448

Consensus CDS

CCDS5989.1

UniProtKB/Swiss-Prot

B4DR10, B8PTI0, E9PDZ8, E9PF76, E9PGY9, O14868, O43199, Q7Z5R8, Q86UC6, Q96QB1, Q9C0E0, Q9H7A2

UniProtKB/TrEMBL

A8K6L7

Related

ENSP00000276297.4, ENST00000276297.9

Conserved Domains (3) summary

cd08908
Location:1315 → 1518

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:454 → 513

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1072 → 1290

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...