ADORA1 adenosine A1 receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADORA1provided by HGNC
Official Full Name: adenosine A1 receptorprovided by HGNC
Primary source: HGNC:HGNC:262
See related: Ensembl:ENSG00000163485 MIM:102775; AllianceGenome:HGNC:262
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RDC7
Summary: The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 15.5), testis (RPKM 10.4) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (203127726..203167405)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (202390478..202430156)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (203096854..203136533)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.
Title: Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.
Comparative Study of Receptor-, Receptor State-, and Membrane-Dependent Cholesterol Binding Sites in A2A and A1 Adenosine Receptors Using Coarse-Grained Molecular Dynamics Simulations.
Title: Comparative Study of Receptor-, Receptor State-, and Membrane-Dependent Cholesterol Binding Sites in A(2A) and A(1) Adenosine Receptors Using Coarse-Grained Molecular Dynamics Simulations.
The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A1-A2A receptor heteromer formation and function.
Title: The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A(1)-A(2A) receptor heteromer formation and function.
Crystal structure of the alpha1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.
Title: Crystal structure of the α(1B)-adrenergic receptor reveals molecular determinants of selective ligand recognition.
Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment.
Title: Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment.
Plasmacytoid dendritic cells recruited by HIF-1alpha/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma.
Title: Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma.
Expression of ADR-alpha1, 2 and ADR-beta2 in cumulus cell culture of infertile women with polycystic ovary syndrome and poor responder who are a candidate for IVF: the novel strategic role of clonidine in this expression.
Title: Expression of ADR-α1, 2 and ADR-β2 in cumulus cell culture of infertile women with polycystic ovary syndrome and poor responder who are a candidate for IVF: the novel strategic role of clonidine in this expression.
NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization.
Title: NanoBiT Complementation to Monitor Agonist-Induced Adenosine A(1) Receptor Internalization.
ADORA1 promotes nasopharyngeal carcinoma cell progression through regulation of PI3K/AKT/GSK-3beta/beta-catenin signaling.
Title: ADORA1 promotes nasopharyngeal carcinoma cell progression through regulation of PI3K/AKT/GSK-3β/β-catenin signaling.
ADORA2A variation and adenosine A1 receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation.
Title: ADORA2A variation and adenosine A(1) receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation.

Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-76157 (e-PCR)
- UniSTS:59052

D1S1699 (e-PCR)
- UniSTS:12997

GDB:452605 (e-PCR)
- UniSTS:157389

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heterotrimeric G-protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables purine nucleoside binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in fatty acid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in mucus secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of acute inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of circadian sleep/wake cycle, non-REM sleep	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glutamate secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mucus secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neurotrophin production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in phagocytosis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nucleoside transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptide secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle cell contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of glomerular filtration	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of respiratory gaseous exchange by nervous system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to purine-containing compound	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in temperature homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in asymmetric synapse	IEA Inferred from Electronic Annotation more info
located_in axolemma	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in calyx of Held	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenosine receptor A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052917.1 RefSeqGene

Range

5022..44701

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000674.3 → NP_000665.1 adenosine receptor A1 isoform 1

See identical proteins and their annotated locations for NP_000665.1

Status: REVIEWED

Source sequence(s)

AC105940, BU740906, DB171678, L22214

Consensus CDS

CCDS1434.1

UniProtKB/Swiss-Prot

A6NFY5, A6NGP4, A8K1L3, B3KXQ4, D2CGD0, P30542, Q6FHK3, Q8TAM8

Related

ENSP00000338435.4, ENST00000337894.9

Conserved Domains (2) summary

pfam00001
Location:26 → 288

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:18 → 137

7tm_4; Olfactory receptor
NM_001048230.2 → NP_001041695.1 adenosine receptor A1 isoform 1

See identical proteins and their annotated locations for NP_001041695.1

Status: REVIEWED

Source sequence(s)

AC105940, AK127752, BU740906, DA343445

Consensus CDS

CCDS1434.1

UniProtKB/Swiss-Prot

A6NFY5, A6NGP4, A8K1L3, B3KXQ4, D2CGD0, P30542, Q6FHK3, Q8TAM8

Related

ENSP00000356205.4, ENST00000367236.8

Conserved Domains (2) summary

pfam00001
Location:26 → 288

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:18 → 137

7tm_4; Olfactory receptor
NM_001365065.1 → NP_001351994.1 adenosine receptor A1 isoform 2

Status: REVIEWED

Source sequence(s)

AC105940

UniProtKB/TrEMBL

B7Z1L9, S5RC53

Conserved Domains (2) summary

cd14964
Location:58 → 74

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:46 → 231

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001365066.1 → NP_001351995.1 adenosine receptor A1 isoform 3

Status: REVIEWED

Source sequence(s)

AC105940

Consensus CDS

CCDS91146.1

UniProtKB/TrEMBL

S5RC53

Conserved Domains (2) summary

cd14964
Location:10 → 26

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 183

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily