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    KIF15 kinesin family member 15 [ Homo sapiens (human) ]

    Gene ID: 56992, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KIF15provided by HGNC
    Official Full Name
    kinesin family member 15provided by HGNC
    Primary source
    HGNC:HGNC:17273
    See related
    Ensembl:ENSG00000163808 MIM:617569; AllianceGenome:HGNC:17273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KLP2; HKLP2; KNSL7; BRDCS2; NY-BR-62
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in centrosome separation; microtubule-based movement; and mitotic spindle assembly. Located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 8.0), bone marrow (RPKM 4.1) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF15 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44761794..44868687)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44777475..44868975)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44803286..44894748)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 501 Neighboring gene KIAA1143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44801624-44802266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19771 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14274 Neighboring gene microRNA 564 Neighboring gene transmembrane protein 42 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44925386-44926063 Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene peptidylprolyl isomerase A pseudogene 18 Neighboring gene transglutaminase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44940040-44940581

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles. Drechsler H, et al. Proc Natl Acad Sci U S A, 2016 Mar 22. PMID 26969727, Free PMC Article
    2. KIF15 contributes to cell proliferation and migration in breast cancer. Gao X, et al. Hum Cell, 2020 Oct. PMID 32578050
    3. Knockdown of Kinase Family 15 Inhibits Cancer Cell Proliferation In vitro and its Clinical Relevance in Triple-Negative Breast Cancer. Sheng J, et al. Curr Mol Med, 2019. PMID 30854965
    4. KIF15 plays a role in promoting the tumorigenicity of melanoma. Yu X, et al. Exp Eye Res, 2019 Aug. PMID 30797758
    5. Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma. Qiao Y, et al. Cell Physiol Biochem, 2018. PMID 30439711

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.
      Title: KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.
    2. Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly.
      Title: Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly.
    3. KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis.
      Title: KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis.
    4. KIF15 knockdown inhibits the development of endometrial cancer by suppressing epithelial-mesenchymal transition and stemness through Wnt/beta-catenin signaling.
      Title: KIF15 knockdown inhibits the development of endometrial cancer by suppressing epithelial-mesenchymal transition and stemness through Wnt/β-catenin signaling.
    5. KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer.
      Title: KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer.
    6. Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer.
      Title: Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer.
    7. PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer.
      Title: PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer.
    8. Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis.
      Title: Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis.
    9. Downregulation of KIF15 inhibits the tumorigenesis of non-small-cell lung cancer via inactivating Raf/MEK/ERK signaling.
      Title: Downregulation of KIF15 inhibits the tumorigenesis of non-small-cell lung cancer via inactivating Raf/MEK/ERK signaling.
    10. K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15.
      Title: K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Braddock-carey syndrome 2
    MedGen: C5774189 OMIM: 619981 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25667

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome separation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of plus-end kinesin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF15
    Names
    kinesin-like 7
    kinesin-like protein 2
    kinesin-like protein 7
    serologically defined breast cancer antigen NY-BR-62

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020242.3 → NP_064627.1  kinesin-like protein KIF15

      See identical proteins and their annotated locations for NP_064627.1

      Status: VALIDATED

      Source sequence(s)
      AB035898, AK307674, AL832908, DR005852
      Consensus CDS
      CCDS33744.1
      UniProtKB/Swiss-Prot
      Q17RV9, Q69YL6, Q96JX7, Q9H280, Q9NS87
      Related
      ENSP00000324020.4, ENST00000326047.9
      Conserved Domains (5) summary
      smart00129
      Location:26 → 370
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1196
      Location:490 → 1331
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01373
      Location:25 → 373
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
      pfam12711
      Location:463 → 551
      Kinesin-relat_1; Kinesin motor
      pfam15908
      Location:1281 → 1376
      HMMR_C; Hyaluronan mediated motility receptor C-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      44761794..44868687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006884.3 → XP_016862373.1  kinesin-like protein KIF15 isoform X1

    2. XM_011533964.4 → XP_011532266.1  kinesin-like protein KIF15 isoform X3

      See identical proteins and their annotated locations for XP_011532266.1

      Conserved Domains (5) summary
      smart00129
      Location:26 → 370
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1196
      Location:490 → 1265
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01373
      Location:25 → 373
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
      pfam12711
      Location:463 → 551
      Kinesin-relat_1; Kinesin motor
      pfam15908
      Location:1215 → 1310
      HMMR_C; Hyaluronan mediated motility receptor C-terminal

    3. XM_017006885.3 → XP_016862374.1  kinesin-like protein KIF15 isoform X2

    4. XM_017006887.3 → XP_016862376.1  kinesin-like protein KIF15 isoform X4

    5. XM_017006889.3 → XP_016862378.1  kinesin-like protein KIF15 isoform X8

    6. XM_047448602.1 → XP_047304558.1  kinesin-like protein KIF15 isoform X6

    7. XM_047448603.1 → XP_047304559.1  kinesin-like protein KIF15 isoform X7

    8. XM_047448601.1 → XP_047304557.1  kinesin-like protein KIF15 isoform X5

    9. XM_017006890.2 → XP_016862379.1  kinesin-like protein KIF15 isoform X9

    10. XM_006713264.4 → XP_006713327.1  kinesin-like protein KIF15 isoform X10

      See identical proteins and their annotated locations for XP_006713327.1

      UniProtKB/TrEMBL
      C9JKA9
      Related
      ENSP00000389982.1, ENST00000425755.5
      Conserved Domains (3) summary
      COG1196
      Location:125 → 901
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12711
      Location:98 → 186
      Kinesin-relat_1; Kinesin motor
      pfam15908
      Location:916 → 1011
      HMMR_C; Hyaluronan mediated motility receptor C-terminal

    RNA

    1. XR_007095708.1 RNA Sequence

      Related
      ENST00000438321.5

    2. XR_007095709.1 RNA Sequence

    3. XR_007095710.1 RNA Sequence

    4. XR_001740214.2 RNA Sequence

    5. XR_001740215.2 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646197.1 Reference GRCh38.p14 PATCHES

      Range
      287144..378606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331546.1 → XP_054187521.1  kinesin-like protein KIF15 isoform X1

    2. XM_054331548.1 → XP_054187523.1  kinesin-like protein KIF15 isoform X3

    3. XM_054331547.1 → XP_054187522.1  kinesin-like protein KIF15 isoform X2

    4. XM_054331549.1 → XP_054187524.1  kinesin-like protein KIF15 isoform X4

    5. XM_054331551.1 → XP_054187526.1  kinesin-like protein KIF15 isoform X6

    6. XM_054331552.1 → XP_054187527.1  kinesin-like protein KIF15 isoform X7

    7. XM_054331553.1 → XP_054187528.1  kinesin-like protein KIF15 isoform X8

    8. XM_054331550.1 → XP_054187525.1  kinesin-like protein KIF15 isoform X5

    9. XM_054331554.1 → XP_054187529.1  kinesin-like protein KIF15 isoform X9

    10. XM_054331555.1 → XP_054187530.1  kinesin-like protein KIF15 isoform X10

      UniProtKB/TrEMBL
      C9JKA9

    RNA

    1. XR_008485721.1 RNA Sequence

    2. XR_008485723.1 RNA Sequence

    3. XR_008485722.1 RNA Sequence

    4. XR_008485724.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      44777475..44868975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347303.1 → XP_054203278.1  kinesin-like protein KIF15 isoform X1

    2. XM_054347305.1 → XP_054203280.1  kinesin-like protein KIF15 isoform X3

    3. XM_054347304.1 → XP_054203279.1  kinesin-like protein KIF15 isoform X2

    4. XM_054347306.1 → XP_054203281.1  kinesin-like protein KIF15 isoform X4

    5. XM_054347308.1 → XP_054203283.1  kinesin-like protein KIF15 isoform X6

    6. XM_054347309.1 → XP_054203284.1  kinesin-like protein KIF15 isoform X7

    7. XM_054347310.1 → XP_054203285.1  kinesin-like protein KIF15 isoform X8

    8. XM_054347307.1 → XP_054203282.1  kinesin-like protein KIF15 isoform X5

    9. XM_054347311.1 → XP_054203286.1  kinesin-like protein KIF15 isoform X9

    10. XM_054347312.1 → XP_054203287.1  kinesin-like protein KIF15 isoform X10

    RNA

    1. XR_008486751.1 RNA Sequence

    2. XR_008486753.1 RNA Sequence

    3. XR_008486752.1 RNA Sequence

    4. XR_008486754.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NS87.1 GenPept UniProtKB/Swiss-Prot:Q9NS87

    Gene LinkOut

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