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    WWC3 WWC family member 3 [ Homo sapiens (human) ]

    Gene ID: 55841, updated on 28-Oct-2024

    Summary

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    Official Symbol
    WWC3provided by HGNC
    Official Full Name
    WWC family member 3provided by HGNC
    Primary source
    HGNC:HGNC:29237
    See related
    Ensembl:ENSG00000047644 MIM:301089; AllianceGenome:HGNC:29237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BM042
    Summary
    This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Ubiquitous expression in lung (RPKM 15.2), placenta (RPKM 10.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See WWC3 in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (10015254..10144474)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (9597786..9727019)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (9983294..10112514)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene shroom family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9833462-9834428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9834429-9835394 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 33 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9891645-9892144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9891143-9891644 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9895839-9896557 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:9907403-9908602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9908687-9909186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9981409-9982292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9982293-9983176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20655 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:10009285-10009817 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:10008750-10009284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10014897-10015530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10015531-10016163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10018119-10018742 Neighboring gene claudin 34 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:10050926-10051426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:10077459-10078176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:10078177-10078894 Neighboring gene Sharpr-MPRA regulatory region 7563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10141885-10142861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20656 Neighboring gene chloride voltage-gated channel 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:10416979-10418178 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:10476778-10477647 Neighboring gene midline 1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:10539598-10539816 Neighboring gene RNA, U6 small nuclear 800, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. WWC3 Inhibits Glioma Cell Proliferation Through Suppressing the Wnt/β-Catenin Signaling Pathway. Wang Y, et al. DNA Cell Biol, 2018 Jan. PMID 29115863
    2. WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression. Han Q, et al. Cell Death Dis, 2021 Apr 9. PMID 33837178, Free PMC Article
    3. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Laine A, et al. Cancer Res, 2021 Aug 15. PMID 34145035, Free PMC Article
    4. Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, et al. Mol Biol Evol, 2014 Jul. PMID 24682284
    5. WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy. Qi S, et al. Mol Cell, 2022 May 19. PMID 35429439

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.
      Title: WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.
    2. WWC3 interacted with T cell factor 4 (TCF4).
      Title: WWC3 Inhibits Glioma Cell Proliferation Through Suppressing the Wnt/β-Catenin Signaling Pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1280

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein WWC3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021467.2 RefSeqGene

      Range
      5001..133724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015691.5 → NP_056506.3  protein WWC3

      Status: VALIDATED

      Source sequence(s)
      AC002365, AC121345, KC987947
      Consensus CDS
      CCDS14136.1
      UniProtKB/Swiss-Prot
      A8KA96, Q659C1, Q9BTQ1, Q9ULE0, T2C6S4
      Related
      ENSP00000370242.6, ENST00000380861.10
      Conserved Domains (3) summary
      cd08680
      Location:727 → 850
      C2_Kibra; C2 domain found in Human protein Kibra
      pfam00397
      Location:62 → 91
      WW; WW domain
      pfam05615
      Location:127 → 244
      THOC7; Tho complex subunit 7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      10015254..10144474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      9597786..9727019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULE0.4 GenPept UniProtKB/Swiss-Prot:Q9ULE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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