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    dlec1 DLEC1 cilia and flagella associated protein [ Danio rerio (zebrafish) ]

    Gene ID: 555583, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dlec1provided by ZNC
    Official Full Name
    DLEC1 cilia and flagella associated proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091204-65
    See related
    Ensembl:ENSDARG00000075825 AllianceGenome:ZFIN:ZDB-GENE-091204-65
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-246l21.2
    Summary
    Predicted to act upstream of or within negative regulation of cell population proliferation. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human DLEC1 (DLEC1 cilia and flagella associated protein). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See dlec1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20332984..20369610, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20188565..20225186, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100334155 Neighboring gene mitogen-activated protein kinase kinase kinase 22 Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene phospholipase C, delta 1a Neighboring gene villin-like Neighboring gene uncharacterized LOC137489234 Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Choksi SP, et al. Development, 2014 Sep. PMID 25139857, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deleted in lung and esophageal cancer protein 1
    Names
    deleted in lung and esophageal cancer 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      20332984..20369610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017353955.3 → XP_017209444.1  deleted in lung and esophageal cancer protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z474, E9QEP3
      Related
      ENSDARP00000112787.1, ENSDART00000143174.2

    2. XM_017353956.3 → XP_017209445.1  deleted in lung and esophageal cancer protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M6YWD1

    3. XM_678134.8 → XP_683226.4  deleted in lung and esophageal cancer protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8N7UUL3
    Nucleotide Protein Strain
    Heading Accession and Version

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