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    unc13d unc-13 homolog D (C. elegans) [ Danio rerio (zebrafish) ]

    Gene ID: 564076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc13dprovided by ZNC
    Official Full Name
    unc-13 homolog D (C. elegans)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110411-188
    See related
    Ensembl:ENSDARG00000078249 AllianceGenome:ZFIN:ZDB-GENE-110411-188
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-140l3.2
    Summary
    Predicted to be involved in secretion. Predicted to act upstream of or within exocytosis. Predicted to be located in endosome. Predicted to be active in exocytic vesicle. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 3. Orthologous to human UNC13D (unc-13 homolog D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See unc13d in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (36474556..36521812, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (35801817..35849919, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:ch211-250n8.1 Neighboring gene unk zinc finger Neighboring gene F-box and WD repeat domain containing 10 Neighboring gene si:ch211-216b21.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of the zebrafish Klf family identifies two genes important for erythroid maturation. Xue Y, et al. Dev Biol, 2015 Jul 15. PMID 26015096
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein unc-13 homolog D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      36474556..36521812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306839.3 → XP_009305114.1  protein unc-13 homolog D

      See identical proteins and their annotated locations for XP_009305114.1

      UniProtKB/TrEMBL
      A0A8M3B4T4, F6NFN1, X1WBE2
      Related
      ENSDARP00000102554.3, ENSDART00000110290.6
      Conserved Domains (3) summary
      cd04009
      Location:931 → 1067
      C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
      cd08676
      Location:104 → 282
      C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
      pfam10540
      Location:811 → 899
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    Nucleotide Protein
    Heading Accession and Version

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