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    snx7 sorting nexin 7 [ Danio rerio (zebrafish) ]

    Gene ID: 431776, updated on 14-Nov-2024

    Summary

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    Official Symbol
    snx7provided by ZNC
    Official Full Name
    sorting nexin 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040704-77
    See related
    Ensembl:ENSDARG00000105185 AllianceGenome:ZFIN:ZDB-GENE-040704-77
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92458
    Summary
    Enables cysteine-type endopeptidase activity. Acts upstream of or within apoptotic process; liver development; and negative regulation of apoptotic process. Predicted to be active in early endosome and phagophore assembly site. Is expressed in gut and liver. Orthologous to human SNX7 (sorting nexin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See snx7 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (30227941..30275308, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (30221677..30269650, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase-related protein type 4 Neighboring gene phospholipid phosphatase related 5b Neighboring gene microRNA 137-2 Neighboring gene uncharacterized LOC137489255 Neighboring gene dihydropyrimidine dehydrogenase a, tandem duplicate 1 Neighboring gene uncharacterized LOC110437717

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish models of human liver development and disease. Wilkins BJ, et al. Compr Physiol, 2013 Jul. PMID 23897685, Free PMC Article
    2. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
    3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002229.2 → NP_001002229.2  sorting nexin-7

      Status: VALIDATED

      Source sequence(s)
      BC074057, CU929325
      UniProtKB/TrEMBL
      A0A0R4IIY5, A0A8M1N046, Q6GMJ0
      Related
      ENSDARP00000133335.1, ENSDART00000168723.2
      Conserved Domains (2) summary
      cd07284
      Location:80 → 195
      PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
      cd07666
      Location:179 → 421
      BAR_SNX7; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      30227941..30275308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162844.5 → XP_005162901.1  sorting nexin-7 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IBS8, A0A8M2B9U9, Q6GMJ0
      Related
      ENSDARP00000131073.1, ENSDART00000164187.3
      Conserved Domains (2) summary
      cd07284
      Location:80 → 195
      PX_SNX7; The phosphoinositide binding Phox Homology domain of Sorting Nexin 7
      cl12013
      Location:179 → 455
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version

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