abat 4-aminobutyrate aminotransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abatprovided by ZNC
Official Full Name: 4-aminobutyrate aminotransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031006-4
See related: Ensembl:ENSDARG00000006031 AllianceGenome:ZFIN:ZDB-GENE-031006-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb880; fj82a01; wu:fj82a01
Summary: Predicted to enable pyridoxal phosphate binding activity. Predicted to be involved in gamma-aminobutyric acid catabolic process. Predicted to act upstream of or within gamma-aminobutyric acid metabolic process. Predicted to be active in mitochondrion. Is expressed in blood; liver; nervous system; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (27833931..27880303, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (27703093..27749461, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables (S)-3-amino-2-methylpropionate transaminase activity	IEA Inferred from Electronic Annotation more info
enables 4-aminobutyrate:2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gamma-aminobutyric acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 4-aminobutyrate aminotransferase, mitochondrial

Names: GABA-T

NP_958906.2

EC 2.6.1.19

XP_068072249.1

EC 2.6.1.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201498.2 → NP_958906.2 4-aminobutyrate aminotransferase, mitochondrial

See identical proteins and their annotated locations for NP_958906.2

Status: VALIDATED

Source sequence(s)

CU464204, EH544013

UniProtKB/TrEMBL

A0A8N7V0P5, I3IRW7

Related

ENSDARP00000125625.1, ENSDART00000151404.2

Conserved Domains (2) summary

COG0160
Location:42 → 500

GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

cl18945
Location:38 → 496

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...