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    hsp90aa1.2 heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 565155, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hsp90aa1.2provided by ZNC
    Official Full Name
    heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031001-3
    See related
    Ensembl:ENSDARG00000024746 AllianceGenome:ZFIN:ZDB-GENE-031001-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb820; hsp90a2; hsp90a.2
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Predicted to be involved in several processes, including cellular response to heat; protein folding; and protein stabilization. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including myelin sheath; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in several structures, including immature eye; mesoderm; musculature system; nervous system; and pericardial region. Orthologous to several human genes including HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See hsp90aa1.2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (53967596..53981618, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (54178150..54192172, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488709 Neighboring gene uncharacterized LOC110438168 Neighboring gene protein phosphatase 2, regulatory subunit B', gamma b Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 Neighboring gene si:dkey-241l7.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis. Etard C, et al. Dev Biol, 2007 Aug 1. PMID 17586488
    2. Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota. Li Q, et al. Foods, 2024 Jan 16. PMID 38254577, Free PMC Article
    3. TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish. Reverendo M, et al. RNA Biol, 2014. PMID 25483040, Free PMC Article
    4. Generation of GCaMP6s-Expressing Zebrafish to Monitor Spatiotemporal Dynamics of Calcium Signaling Elicited by Heat Stress. Li F, et al. Int J Mol Sci, 2021 May 24. PMID 34074030, Free PMC Article
    5. Chronic exposure to anthropogenic and climate related stressors alters transcriptional responses in the liver of zebrafish (Danio rerio) across multiple generations. Luu I, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2021 Feb. PMID 33141083

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hsp90aa1.2 activity is required for fast and efficient cell divisions during the guided migration of primordial germ cells towards the gonad region
      Title: Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to antibiotic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to cold ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
    Names
    heat shock protein 90-alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045073.1 → NP_001038538.1  heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2

      See identical proteins and their annotated locations for NP_001038538.1

      Status: PROVISIONAL

      Source sequence(s)
      CR381646
      UniProtKB/TrEMBL
      B3DIL2, Q5RG12
      Related
      ENSDARP00000026065.8, ENSDART00000023550.11
      Conserved Domains (3) summary
      smart00387
      Location:38 → 189
      HATPase_c; Histidine kinase-like ATPases
      PTZ00272
      Location:16 → 734
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:194 → 724
      HSP90; Hsp90 protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      53967596..53981618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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