adar adenosine deaminase RNA specific [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adarprovided by ZNC
Official Full Name: adenosine deaminase RNA specificprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000616-5
See related: Ensembl:ENSDARG00000012389 AllianceGenome:ZFIN:ZDB-GENE-000616-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: red1; drada; wu:fc22a02
Summary: Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Acts upstream of or within anterior/posterior axis specification, embryo. Predicted to be active in cytoplasm and nucleolus. Is expressed in brain and nervous system. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (23531583..23559531)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (23616551..23644499)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The presence of ADA activity in zebrafish brain may be important to regulate the adenosine/inosine levels in the CNS of this species
Title: Kinetic characterization of adenosine deaminase activity in zebrafish (Danio rerio) brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA-specific adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info
involved_in adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior axis specification, embryo	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: double-stranded RNA-specific adenosine deaminase

NP_571671.2

EC 3.5.4.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131596.2 → NP_571671.2 double-stranded RNA-specific adenosine deaminase

See identical proteins and their annotated locations for NP_571671.2

Status: VALIDATED

Source sequence(s)

CR533578, EB919680

UniProtKB/TrEMBL

A0A8M1P8J0, E9QIW2

Related

ENSDARP00000115965.1, ENSDART00000146708.3

Conserved Domains (4) summary

smart00550
Location:252 → 319

Zalpha; Z-DNA-binding domain in adenosine deaminases

smart00358
Location:744 → 809

DSRM; Double-stranded RNA binding motif

smart00552
Location:957 → 1338

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cd00048
Location:868 → 934

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...