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    cul5b cullin 5b [ Danio rerio (zebrafish) ]

    Gene ID: 100006147, updated on 14-Nov-2024

    Summary

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    Official Symbol
    cul5bprovided by ZNC
    Official Full Name
    cullin 5bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091113-45
    See related
    Ensembl:ENSDARG00000004260 AllianceGenome:ZFIN:ZDB-GENE-091113-45
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-111i17.3
    Summary
    Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in telencephalon. Orthologous to human CUL5 (cullin 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See cul5b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22124736..22143190)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (22088057..22106553)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ELMO/CED-12 domain containing 1 Neighboring gene solute carrier family 35 member F2 Neighboring gene calpain 5b Neighboring gene uncharacterized LOC137488807 Neighboring gene olfactory marker protein b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cullin-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cullin-5
    Names
    Vasopressin-activated calcium-mobilizing receptor-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      22124736..22143190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161244.5 → XP_005161301.1  cullin-5 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B8G3, F1QFY1
      Related
      ENSDARP00000109586.2, ENSDART00000130179.3
      Conserved Domains (3) summary
      smart00182
      Location:458 → 601
      CULLIN; Cullin
      pfam00888
      Location:20 → 686
      Cullin; Cullin family
      pfam10557
      Location:728 → 787
      Cullin_Nedd8; Cullin protein neddylation domain

    2. XM_001922844.7 → XP_001922879.1  cullin-5 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IGP7, A0A8M1QHT0
      Related
      ENSDARP00000132713.2, ENSDART00000172573.2
      Conserved Domains (3) summary
      smart00182
      Location:443 → 586
      CULLIN; Cullin
      pfam00888
      Location:20 → 671
      Cullin; Cullin family
      pfam10557
      Location:713 → 772
      Cullin_Nedd8; Cullin protein neddylation domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395349.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      288163..306588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474452.2 → XP_021330127.1  cullin-5 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PFX7
      Conserved Domains (2) summary
      pfam00888
      Location:20 → 698
      Cullin; Cullin family
      pfam10557
      Location:740 → 799
      Cullin_Nedd8; Cullin protein neddylation domain

    2. XM_021474454.2 → XP_021330129.1  cullin-5 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PYY4
      Conserved Domains (2) summary
      pfam00888
      Location:20 → 683
      Cullin; Cullin family
      pfam10557
      Location:725 → 784
      Cullin_Nedd8; Cullin protein neddylation domain

    3. XM_021474453.2 → XP_021330128.1  cullin-5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PSY3
      Conserved Domains (2) summary
      pfam00888
      Location:20 → 686
      Cullin; Cullin family
      pfam10557
      Location:728 → 787
      Cullin_Nedd8; Cullin protein neddylation domain

    4. XM_021474455.2 → XP_021330130.1  cullin-5 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q9W4
      Conserved Domains (2) summary
      pfam00888
      Location:20 → 671
      Cullin; Cullin family
      pfam10557
      Location:713 → 772
      Cullin_Nedd8; Cullin protein neddylation domain
    Nucleotide Protein
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