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    fuca1.1 alpha-L-fucosidase 1, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 335494, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fuca1.1provided by ZNC
    Official Full Name
    alpha-L-fucosidase 1, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7434
    See related
    Ensembl:ENSDARG00000035890 AllianceGenome:ZFIN:ZDB-GENE-030131-7434
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fuca1; wu:fj17c05
    Summary
    Predicted to enable alpha-L-fucosidase activity. Predicted to be involved in fucose metabolic process and glycoside catabolic process. Predicted to act upstream of or within carbohydrate metabolic process and lipid metabolic process. Predicted to be located in membrane. Predicted to be active in lysosome. Is expressed in several structures, including EVL; epidermis; periderm; sensory system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to human FUCA1 (alpha-L-fucosidase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See fuca1.1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (32495419..32500258, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (32908299..32913138, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase Neighboring gene alpha-L-fucosidase 1, tandem duplicate 2 Neighboring gene zinc finger and BTB domain containing 8B Neighboring gene hes related family bHLH transcription factor with YRPW motif like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential expression of the duplicated cellular retinoic acid-binding protein 2 genes (crabp2a and crabp2b) during zebrafish embryonic development. Sharma MK, et al. Gene Expr Patterns, 2005 Feb. PMID 15661643
    2. A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Mercer SE, et al. Dev Biol, 2013 Oct 15. PMID 23939298, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-L-fucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-L-fucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-L-fucosidase 1, tandem duplicate 1
    Names
    fucosidase, alpha-L- 1, tissue, tandem duplicate 1
    NP_997905.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212740.1 → NP_997905.1  alpha-L-fucosidase 1, tandem duplicate 1 precursor

      See identical proteins and their annotated locations for NP_997905.1

      Status: PROVISIONAL

      Source sequence(s)
      BC050158
      UniProtKB/TrEMBL
      Q7ZW80
      Related
      ENSDARP00000052103.5, ENSDART00000052104.6
      Conserved Domains (3) summary
      smart00812
      Location:23 → 401
      Alpha_L_fucos; Alpha-L-fucosidase
      COG3669
      Location:51 → 371
      AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]
      pfam16757
      Location:366 → 448
      Fucosidase_C; Alpha-L-fucosidase C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      32495419..32500258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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