fosl2 FOS like 2, AP-1 transcription factor subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fosl2provided by ZNC
Official Full Name: FOS like 2, AP-1 transcription factor subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070209-164
See related: Ensembl:ENSDARG00000040623 AllianceGenome:ZFIN:ZDB-GENE-070209-164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fra2; wu:fl03b09; wu:fl17h04; xx:fl17h04; zgc:158347
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of cardiac muscle cell myoblast differentiation. Predicted to be active in nucleus. Is expressed in several structures, including brain; hatching gland; head; pericardial region; and trunk. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (41302648..41318554)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (41313748..41329680)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.
Title: Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.
Fos-like antigen 2 (Fosl2), potentiates the rate of myocardial accretion from the zebrafish second heart field.
Title: The AP-1 transcription factor component Fosl2 potentiates the rate of myocardial differentiation from the zebrafish second heart field.

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General gene information

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Markers

fl17h04.x1 (e-PCR)
- UniSTS:202018

fl03b09.x1 (e-PCR)
- UniSTS:201865

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cardiac muscle cell myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fos-related antigen 2

Names: fos-like antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082998.2 → NP_001076467.1 fos-related antigen 2 isoform 1

See identical proteins and their annotated locations for NP_001076467.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CABZ01079144, CABZ01079145, CABZ01079146

UniProtKB/TrEMBL

A0A8M1NDK2, A2RUX8

Related

ENSDARP00000059479.4, ENSDART00000059480.5

Conserved Domains (1) summary

cd14721
Location:135 → 188

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
NM_001362607.1 → NP_001349536.1 fos-related antigen 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

CABZ01079144, CABZ01079145, CABZ01079146

UniProtKB/TrEMBL

A0A8M2BKU3

Conserved Domains (1) summary

cd14721
Location:96 → 149

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain