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    waslb WASP like actin nucleation promoting factor b [ Danio rerio (zebrafish) ]

    Gene ID: 394034, updated on 2-Nov-2024

    Summary

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    Official Symbol
    waslbprovided by ZNC
    Official Full Name
    WASP like actin nucleation promoting factor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-718
    See related
    Ensembl:ENSDARG00000006283 AllianceGenome:ZFIN:ZDB-GENE-040426-718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    reph; wasl; N-waspb; rephaim; unm_mh22; unm_dmh22; zgc:55478; zgc:77237
    Summary
    Predicted to enable actin binding activity. Acts upstream of or within dermal bone morphogenesis; myeloid cell differentiation; and myoblast fusion. Predicted to be located in cytoplasm; cytoskeleton; and nucleus. Predicted to be active in plasma membrane. Is expressed in several structures, including EVL; notochord; pectoral fin bud; periderm; and retina. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See waslb in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (4071138..4111767)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (4070474..4102854)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 37b Neighboring gene transmembrane protein 229A Neighboring gene leiomodin 2 (cardiac) b Neighboring gene ankyrin repeat and SOCS box containing 15b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Luo Z, et al. Dev Cell, 2022 Jul 11. PMID 35709765, Free PMC Article
    2. Latent developmental potential to form limb-like skeletal structures in zebrafish. Hawkins MB, et al. Cell, 2021 Feb 18. PMID 33545089
    3. Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form. Henke K, et al. Genetics, 2017 Oct. PMID 28835471, Free PMC Article
    4. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Fan HB, et al. Blood, 2014 Aug 21. PMID 24990885
    5. A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. Bielczyk-Maczyńska E, et al. PLoS Genet, 2014 Jul. PMID 25010335, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55478

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dermal bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myoblast fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WASP like actin nucleation promoting factor b
    Names
    Wiskott-Aldrich syndrome, like
    Wiskott-Aldrich syndrome-like b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201059.2 → NP_957353.2  WASP like actin nucleation promoting factor b

      See identical proteins and their annotated locations for NP_957353.2

      Status: PROVISIONAL

      Source sequence(s)
      BC066424
      UniProtKB/TrEMBL
      Q6NYX7
      Related
      ENSDARP00000005823.6, ENSDART00000028016.8
      Conserved Domains (3) summary
      cd01205
      Location:37 → 131
      EVH1_WASP-like; WASP family proteins EVH1 domain
      pfam00786
      Location:215 → 270
      PBD; P21-Rho-binding domain
      pfam02205
      Location:415 → 438
      WH2; WH2 motif

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      4071138..4111767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474971.2 → XP_021330646.1  WASP like actin nucleation promoting factor b isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q5U1
      Conserved Domains (3) summary
      cd01205
      Location:9 → 103
      EVH1_WASP-like; WASP family proteins EVH1 domain
      pfam00786
      Location:187 → 244
      PBD; P21-Rho-binding domain
      pfam02205
      Location:387 → 410
      WH2; WH2 motif

    2. XM_005164482.5 → XP_005164539.1  WASP like actin nucleation promoting factor b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBM4
      Conserved Domains (3) summary
      cd01205
      Location:37 → 131
      EVH1_WASP-like; WASP family proteins EVH1 domain
      pfam00786
      Location:207 → 262
      PBD; P21-Rho-binding domain
      pfam02205
      Location:407 → 430
      WH2; WH2 motif
    Nucleotide Protein Strain
    Heading Accession and Version

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